Title:
The single-stranded insulin agonist in which high activity is shown to an insulin receptor
Document Type and Number:
Japanese Patent JP5969469
Kind Code:
B2
Abstract:
Single chain insulin analogs are provided having high potency and specificity for the insulin receptor. As disclosed herein optimally sized linking moieties can be used to link human insulin A and B chains, or analogs or derivatives thereof, wherein the carboxy terminus of the B25 amino acid of the B chain is linked to the amino terminus of the A1 amino acid of the A chain via the intervening linking moiety. In on embodiment the linking moiety comprises a polyethylene glycol of 6-16 monomer units and in an alternative embodiment the linking moiety comprises a non-native amino acid sequence derived form the IGF-1 C-peptide and comprising at least 8 amino acids and no more than 12 amino acid in length. Also disclosed are prodrug and conjugate derivatives of the single chain insulin analogs.
More Like This:
Inventors:
De March, Richard, Dee.
Azuriel, Julia
Cowl, zac
Jonathan Mayers
Parody Todd
Cao, Yang
Azuriel, Julia
Cowl, zac
Jonathan Mayers
Parody Todd
Cao, Yang
Application Number:
JP2013515513A
Publication Date:
August 17, 2016
Filing Date:
June 16, 2011
Export Citation:
Assignee:
INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION
International Classes:
C07K14/62; A61K38/28; A61P3/10; A61P43/00
Domestic Patent References:
| JP2010500031A | ||||
| JP2008533100A |
Foreign References:
| WO1996034882A1 | ||||
| WO2009099763A1 |
Other References:
Mol Endocrinol,2009年,Vol.23,No.5,p.679-688
Attorney, Agent or Firm:
Isshiki International Patent Service Corporation