Title:
VACCINE FOR PREVENTION OF BREAST CANCER RECURRENCE
Document Type and Number:
Japanese Patent JP2018008960
Kind Code:
A
Abstract:
PROBLEM TO BE SOLVED: To provide a method to induce and maintain a protective cytotoxic T-lymphocyte response to a peptide of the HER2/neu oncogene, GP2, with the effect of inducing and maintaining protective or therapeutic immunity against breast cancer in a patient in clinical remission, including patients having low to intermediate levels of HER2/neu expression.SOLUTION: According to the present invention, there is provided a method that comprise administering to the patient an effective amount of a vaccine composition comprising a pharmaceutically acceptable carrier, an adjuvant such as GM-CSF, and the GP2 peptide. The methods may further comprise administering a periodic booster vaccine dose as needed due to declining GP2-specific T cell immunity. According to the present invention, there are also provided vaccine compositions for use in the method.SELECTED DRAWING: Figure 1-1
More Like This:
Inventors:
GEORGE PEOPLES
SATHIBALAN PONNIAH
SATHIBALAN PONNIAH
Application Number:
JP2017135106A
Publication Date:
January 18, 2018
Filing Date:
July 11, 2017
Export Citation:
Assignee:
HENRY M JACKSON FOUND FOR THE ADVANCEMENT OF MILITARY MEDICINE INC THE
International Classes:
A61K39/00; A61K38/08; A61K39/39; A61K39/395; A61P15/00; A61P35/00; A61P37/04; A61P43/00
Domestic Patent References:
| JP6220111B2 | 2017-10-25 |
Other References:
BREAST CANCER RES.TREAT., vol. VOL.106, SUPPL.1, JPN6013059480, 2007, pages P.S30-S31, 302
"Intra-antigenic Epitope Spreading in HLA-A2+ Breast Cancer Patients Vaccinated With a MHC Class i Pe", J.IMMUNOTHERAPY, vol. 30, no. 8, JPN6013059478, 2007, pages 8 - 6
"Intra-antigenic Epitope Spreading in HLA-A2+ Breast Cancer Patients Vaccinated With a MHC Class i Pe", J.IMMUNOTHERAPY, vol. 30, no. 8, JPN6013059478, 2007, pages 8 - 6
Attorney, Agent or Firm:
Yusuke Hiraki
Satoshi Fujita
Eiichi Arai
Natsuo Tanaka
Satoshi Fujita
Eiichi Arai
Natsuo Tanaka