Title:
VARIANT DERIVED FROM ActRIIB AND USE THEREOF
Document Type and Number:
Japanese Patent JP2018108112
Kind Code:
A
Abstract:
PROBLEM TO BE SOLVED: To provide an agonist functioning as a potent regulator of TGF-β signal transduction.SOLUTION: In an aspect, the present invention provides a composition and method for control (promotion or inhibition) of the growth of tissues such as bone, cartilage, muscle, fat and/or nerve tissues. The present invention provides a method of screening a compound controlling the activity of ActRIIB protein and/or ActRIIB ligand. The composition and method are useful for therapy of a disease related to abnormal activity of ActRIIB protein and/or ActRIIB ligand.SELECTED DRAWING: Figure 1
Inventors:
KNOPF JOHN
KUMAR RAVINDRA
JASBIR SEEHRA
KUMAR RAVINDRA
JASBIR SEEHRA
Application Number:
JP2018067000A
Publication Date:
July 12, 2018
Filing Date:
March 30, 2018
Export Citation:
Assignee:
ACCELERON PHARMA INC
International Classes:
C12N15/12; A61K38/16; A61P3/00; A61P3/04; A61P3/10; A61P13/08; A61P21/00; A61P21/04; A61P25/00; A61P35/00; A61P43/00; C07K14/47; C12N5/10; C12N15/63; C12P21/00
Domestic Patent References:
| JP2006516886A | 2006-07-13 |
Foreign References:
| WO2006012627A2 | 2006-02-02 |
Attorney, Agent or Firm:
Hidesaku Yamamoto
Natsuki Morishita
Natsuki Morishita