1,3,4-OXADIAZOLE DERIVATIVE COMPOUNDS AS HISTONE DEACETYLASE 6 INHIBITOR, AND USES THEREOF

Title:

1,3,4-OXADIAZOLE DERIVATIVE COMPOUNDS AS HISTONE DEACETYLASE 6 INHIBITOR, AND USES THEREOF

Document Type and Number:

WIPO Patent Application WO/2023/195809

Kind Code:

A1

Abstract:

The present invention relates to a novel compound having histone deacetylase 6 (HDAC6) inhibitory activity, a method for preparing the same, and uses thereof. The novel compound according to the present invention, a stereoisomer thereof or a pharmaceutically acceptable salt thereof has HDAC6 inhibitory activity, and is effective for preventing or treating HDAC6-mediated diseases including cancer, inflammatory diseases, autoimmune diseases, neurological or neurodegenerative diseases.

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Inventors:

LEE CHANG SIK (KR)
OH JUNG TAEK (KR)
SONG HYESEUNG (KR)
KIM HYUNJIN MICHAEL (KR)

Application Number:

PCT/KR2023/004684

Publication Date:

October 12, 2023

Filing Date:

April 06, 2023

Export Citation:

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Assignee:

CHONG KUN DANG PHARMACEUTICAL CORP (KR)

International Classes:

C07D271/10; A61K31/496; A61K31/4995; A61K31/5377; A61K31/541; A61P25/28; A61P29/00; A61P35/00; A61P37/00; C07D413/12

Domestic Patent References:

WO2017018803A1	2017-02-02
WO2017018804A1	2017-02-02
WO2020264437A1	2020-12-30

Foreign References:

US20190185462A1	2019-06-20
EP3919055A1	2021-12-08

Attorney, Agent or Firm:

KIM, Kyeongkyo et al. (KR)

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