Title:
PHARMACEUTICAL COMPOSITION FOR TREATING OR PREVENTING CANCER WITH LOW EXPRESSION LEVEL OF HER2
Document Type and Number:
WIPO Patent Application WO/2023/195810
Kind Code:
A1
Abstract:
Provided are a pharmaceutical composition and a method for the treatment and/or prevention of HER2-low expressing and/or FcγRI-expressing cancers using anti-4-1BB/anti-HER2 bispecific antibodies.
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Inventors:
LEE EUNJUNG (KR)
LEE EUN-JUNG (KR)
KIM JUN HWAN (KR)
CHOI MINJI (KR)
SHIN JANG WOO (KR)
CHUNG HYEJIN (KR)
LEE YANGSOON (KR)
SON WONJUN (KR)
LEE EUN-JUNG (KR)
KIM JUN HWAN (KR)
CHOI MINJI (KR)
SHIN JANG WOO (KR)
CHUNG HYEJIN (KR)
LEE YANGSOON (KR)
SON WONJUN (KR)
Application Number:
PCT/KR2023/004686
Publication Date:
October 12, 2023
Filing Date:
April 06, 2023
Export Citation:
Assignee:
YUHAN CORP (KR)
International Classes:
C07K16/28; A61K39/00; A61P35/00; C07K16/32
Foreign References:
| US20210024650A1 | 2021-01-28 | |||
| US20220041750A1 | 2022-02-10 | |||
| US20210024610A1 | 2021-01-28 | |||
| US20210024638A1 | 2021-01-28 | |||
| US20200062854A1 | 2020-02-27 |
Other References:
LEE E., H. CHUNG, Y. LEE, E-J. LEE, Y.B. PARK, Y. KIM, J.Y. PARK, S. AHN, J. KIM, K.K. AHN, K. PARK, W. SON, D. YEOM, J. JUNG, J. : "544P A novel HER2/4-1BB bispecific antibody, YH32367 (ABL105) exerts significant anti-tumor effects through tumor-directed T cell activation", ANNALS OF ONCOLOGY, vol. 32, no. S5, 1 September 2021 (2021-09-01), pages S60 - S608, XP093096083, ISSN: 0923-7534, DOI: 10.1016/j.annonc.2021.08.1066
LEE EUNJUNG, HYEJIN CHUNG; YANGSOON LEE; EUN-JUNG LEE; YOUNG BONG PARK; JU YOUNG PARK; SUJIN AHN; JUNHWAN KIM; KYOUNG KYU AHN; KYE: "Abstract 1139: A novel HER2/4-1BB bispecific antibody, YH32367 (ABL105) exhibits the optimal efficacy and superior safety profile through tumor-directed 4-1BB agonism | | American Association for Cancer Research", CANCER RESEARCH POSTER PRESENTATIONS, vol. 82, no. 12_Suppl., 15 June 2022 (2022-06-15), XP093096085, DOI: 10.1158/1538-7445.AM2022-1139
LEE EUNJUNG, HYEJIN CHUNG; YANGSOON LEE; EUN-JUNG LEE; YOUNG BONG PARK; JU YOUNG PARK; SUJIN AHN; JUNHWAN KIM; KYOUNG KYU AHN; KYE: "Abstract 1139: A novel HER2/4-1BB bispecific antibody, YH32367 (ABL105) exhibits the optimal efficacy and superior safety profile through tumor-directed 4-1BB agonism | | American Association for Cancer Research", CANCER RESEARCH POSTER PRESENTATIONS, vol. 82, no. 12_Suppl., 15 June 2022 (2022-06-15), XP093096085, DOI: 10.1158/1538-7445.AM2022-1139
Attorney, Agent or Firm:
YOU ME PATENT AND LAW FIRM (KR)
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