Title:
ACTIVATION OF LYMPHOCYTE POPULATIONS EXPRESSING NKG2D USING ANTI-NKG2D ANTIBODIES AND LIGAND DERIVATIVES
Document Type and Number:
WIPO Patent Application WO2002068615
Kind Code:
A3
Abstract:
The present invention provides various methods for stimulating a cell expressing an NKG2D receptor, including artificially engineered cell populations. Provided, in accordance with the invention, are monoclonal antibodies that bind to NKG2D extracellular domains and facilitate the interaction of other NKG2D domains with DAP10. Of particular interest are treating cancers and viral infections, and the stimulation, both in vivo and ex vivo, of cytokine secretion.
Inventors:
SPIES THOMAS (US)
SPIES VERONIKA (US)
SPIES VERONIKA (US)
Application Number:
PCT/US2002/005343
Publication Date:
August 07, 2003
Filing Date:
February 21, 2002
Export Citation:
Assignee:
HUTCHINSON FRED CANCER RES (US)
SPIES THOMAS (US)
SPIES VERONIKA (US)
SPIES THOMAS (US)
SPIES VERONIKA (US)
International Classes:
A61P31/00; A61P35/00; A61P37/00; C07K14/47; C12N5/08; (IPC1-7): C12N5/08; A61K35/14; A61K39/00; A61K39/395; A61P31/00; A61P35/00; A61P37/00
Domestic Patent References:
| WO1992017198A1 | 1992-10-15 | |||
| WO2001071005A2 | 2001-09-27 |
Other References:
DIEFENBACH ANDREAS ET AL: "Ligands for the murine NKG2D receptor: Expression by tumor cells and activation of NK cells and macrophages.", NATURE IMMUNOLOGY, vol. 1, no. 2, August 2000 (2000-08-01), pages 119 - 126, XP008016406, ISSN: 1529-2908
LEHNER T: "IMMUNOPATHOGENESIS OF BEHCET'S DISEASE", ANNALES DE MEDECINE INTERNE, MASSON, PARIS, FR, vol. 150, no. 6, October 1999 (1999-10-01), pages 483 - 487, XP000994993, ISSN: 0003-410X
BAUER STEFAN ET AL: "Activation of NK cells and T cells by NKG2D, a receptor for stress-inducible MICA.", SCIENCE (WASHINGTON D C), vol. 285, no. 5428, 30 July 1999 (1999-07-30), pages 727 - 729, XP002177592, ISSN: 0036-8075
GROH V ET AL: "Broad tumor-associated expression and recognition by tumor-derived gamma delta T cells of MICA and MICB.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. UNITED STATES 8 JUN 1999, vol. 96, no. 12, 8 June 1999 (1999-06-08), pages 6879 - 6884, XP002240479, ISSN: 0027-8424
WU JUN ET AL: "An activating immunoreceptor complex formed by NKG2D and DAP10.", SCIENCE (WASHINGTON D C), vol. 285, no. 5428, 30 July 1999 (1999-07-30), pages 730 - 732, XP002240480, ISSN: 0036-8075
GROH VERONIKA ET AL: "Costimulation of CD8alphabeta T cells by NKG2D via engagement by MIC induced on virus-infected cells.", NATURE IMMUNOLOGY, vol. 2, no. 3, March 2001 (2001-03-01), pages 255 - 260, XP008016411, ISSN: 1529-2908
KUBIN M ET AL: "ULBP1, 2, 3: novel MHC class I-related molecules that bind to human cytomegalovirus glycoprotein UL16, activate NK cells.", EUROPEAN JOURNAL OF IMMUNOLOGY. GERMANY MAY 2001, vol. 31, no. 5, May 2001 (2001-05-01), pages 1428 - 1437, XP002240482, ISSN: 0014-2980
LEHNER T: "IMMUNOPATHOGENESIS OF BEHCET'S DISEASE", ANNALES DE MEDECINE INTERNE, MASSON, PARIS, FR, vol. 150, no. 6, October 1999 (1999-10-01), pages 483 - 487, XP000994993, ISSN: 0003-410X
BAUER STEFAN ET AL: "Activation of NK cells and T cells by NKG2D, a receptor for stress-inducible MICA.", SCIENCE (WASHINGTON D C), vol. 285, no. 5428, 30 July 1999 (1999-07-30), pages 727 - 729, XP002177592, ISSN: 0036-8075
GROH V ET AL: "Broad tumor-associated expression and recognition by tumor-derived gamma delta T cells of MICA and MICB.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. UNITED STATES 8 JUN 1999, vol. 96, no. 12, 8 June 1999 (1999-06-08), pages 6879 - 6884, XP002240479, ISSN: 0027-8424
WU JUN ET AL: "An activating immunoreceptor complex formed by NKG2D and DAP10.", SCIENCE (WASHINGTON D C), vol. 285, no. 5428, 30 July 1999 (1999-07-30), pages 730 - 732, XP002240480, ISSN: 0036-8075
GROH VERONIKA ET AL: "Costimulation of CD8alphabeta T cells by NKG2D via engagement by MIC induced on virus-infected cells.", NATURE IMMUNOLOGY, vol. 2, no. 3, March 2001 (2001-03-01), pages 255 - 260, XP008016411, ISSN: 1529-2908
KUBIN M ET AL: "ULBP1, 2, 3: novel MHC class I-related molecules that bind to human cytomegalovirus glycoprotein UL16, activate NK cells.", EUROPEAN JOURNAL OF IMMUNOLOGY. GERMANY MAY 2001, vol. 31, no. 5, May 2001 (2001-05-01), pages 1428 - 1437, XP002240482, ISSN: 0014-2980
Download PDF: