Title:
INTERFERON REGULATORY FACTOR-1/HUMAN ESTROGEN RECEPTOR FUSION PROTEIN AND ITS USE FOR TREATING CARCINOMAS
Document Type and Number:
WIPO Patent Application WO2002068614
Kind Code:
A3
Abstract:
The invention relates to an interferon regulatory factor-1/human estrogen receptor fusion protein which is reversibly activatible by beta -estradiol and its use for treating carcinomas, particularly for treating hepatocellular carcinoma.
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Inventors:
KROEGER ANDREA (DE)
GEISSLER MICHAEL (DE)
HAUSER HANSJOERG (DE)
GEISSLER MICHAEL (DE)
HAUSER HANSJOERG (DE)
Application Number:
PCT/EP2002/002036
Publication Date:
November 07, 2002
Filing Date:
February 26, 2002
Export Citation:
Assignee:
BIOTECHNOLOG FORSCHUNG GMBH (DE)
KROEGER ANDREA (DE)
GEISSLER MICHAEL (DE)
HAUSER HANSJOERG (DE)
KROEGER ANDREA (DE)
GEISSLER MICHAEL (DE)
HAUSER HANSJOERG (DE)
International Classes:
C12N15/09; A61K31/7088; A61K35/12; A61K35/76; A61K38/00; A61K39/00; A61K39/002; A61K39/02; A61K39/12; A61K48/00; A61P31/00; A61P35/00; A61P37/04; C07K14/47; C07K14/705; C07K14/72; C07K19/00; C12N5/10; C12N15/62; (IPC1-7): C07K14/47; C07K14/72; A61K39/00; A61K48/00; C12N15/62
Domestic Patent References:
| WO1994006818A1 | 1994-03-31 |
Foreign References:
| EP1046710A1 | 2000-10-25 |
Other References:
YIM J H ET AL: "IFN regulatory factor-1 gene transfer into an aggressive, nonimmunogenic sarcoma suppresses the malignant phenotype and enhances immunogenicity in syngeneic mice.", JOURNAL OF IMMUNOLOGY (BALTIMORE, MD.: 1950) UNITED STATES 1 FEB 1997, vol. 158, no. 3, 1 February 1997 (1997-02-01), pages 1284 - 1292, XP001079506, ISSN: 0022-1767
KROGER A (REPRINT) ET AL: "Interferon regulatory factor -1, a potential target for tumor therapy", EUROPEAN CYTOKINE NETWORK, (SEP 1998) VOL. 9, NO. 3, PP. 385-385. PUBLISHER: JOHN LIBBEY EUROTEXT LTD, 127 AVE DE LA REPUBLIQUE, 92120 MONTROUGE, FRANCE. ISSN: 1148-5493., NATL RES INST BIOTECHNOL, GBF, DEPT GENE REGULAT & DIFFERENTIAT, D-38124 BRAUNSCHWEIG, GERMANY, XP001084677
TANAKA NOBUYUKI ET AL: "The interferon regulatory factors and oncogenesis.", SEMINARS IN CANCER BIOLOGY, vol. 10, no. 2, April 2000 (2000-04-01), pages 73 - 81, XP002208226, ISSN: 1044-579X
KIRCHHOFF S ET AL: "Interferon regulatory factor 1 (IRF-1) mediates cell growth inhibition by transactivation of downstream target genes", NUCLEIC ACIDS RESEARCH, OXFORD UNIVERSITY PRESS, SURREY, GB, vol. 21, no. 12, 1993, pages 2881 - 2889, XP002121655, ISSN: 0305-1048
KROEGER ANDREA ET AL: "Growth suppression of the hepatocellular carcinoma cell line Hepa1-6 by an activatable interferon regulatory factor-1 in mice.", CANCER RESEARCH, vol. 61, no. 6, 15 March 2001 (2001-03-15), pages 2609 - 2617, XP001080034, ISSN: 0008-5472
KROGER A (REPRINT) ET AL: "Interferon regulatory factor -1, a potential target for tumor therapy", EUROPEAN CYTOKINE NETWORK, (SEP 1998) VOL. 9, NO. 3, PP. 385-385. PUBLISHER: JOHN LIBBEY EUROTEXT LTD, 127 AVE DE LA REPUBLIQUE, 92120 MONTROUGE, FRANCE. ISSN: 1148-5493., NATL RES INST BIOTECHNOL, GBF, DEPT GENE REGULAT & DIFFERENTIAT, D-38124 BRAUNSCHWEIG, GERMANY, XP001084677
TANAKA NOBUYUKI ET AL: "The interferon regulatory factors and oncogenesis.", SEMINARS IN CANCER BIOLOGY, vol. 10, no. 2, April 2000 (2000-04-01), pages 73 - 81, XP002208226, ISSN: 1044-579X
KIRCHHOFF S ET AL: "Interferon regulatory factor 1 (IRF-1) mediates cell growth inhibition by transactivation of downstream target genes", NUCLEIC ACIDS RESEARCH, OXFORD UNIVERSITY PRESS, SURREY, GB, vol. 21, no. 12, 1993, pages 2881 - 2889, XP002121655, ISSN: 0305-1048
KROEGER ANDREA ET AL: "Growth suppression of the hepatocellular carcinoma cell line Hepa1-6 by an activatable interferon regulatory factor-1 in mice.", CANCER RESEARCH, vol. 61, no. 6, 15 March 2001 (2001-03-15), pages 2609 - 2617, XP001080034, ISSN: 0008-5472
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