Title:
AGENT FOR LOWERING PROLACTIN
Document Type and Number:
WIPO Patent Application WO2000030623
Kind Code:
A3
Abstract:
The present invention relates to an agent which lowers prolactin and which comprises at least one bicyclic diterpene of the labdan or cleordan type (I), (II), (III), (IV), whereby R1 is H, C1-C3-alkyl or C1-C3-acyl.
Inventors:
WUTTKE WOLFGANG (DE)
JARRY HUBERTUS (DE)
POPP MICHAEL (DE)
CHRISTOFFEL VOLKER (DE)
SPENGLER BARBARA (DE)
JARRY HUBERTUS (DE)
POPP MICHAEL (DE)
CHRISTOFFEL VOLKER (DE)
SPENGLER BARBARA (DE)
Application Number:
PCT/EP1999/008507
Publication Date:
August 31, 2000
Filing Date:
November 05, 1999
Export Citation:
Assignee:
BIONORICA ARZNEIMITTEL GMBH (DE)
WUTTKE WOLFGANG (DE)
JARRY HUBERTUS (DE)
POPP MICHAEL (DE)
CHRISTOFFEL VOLKER (DE)
SPENGLER BARBARA (DE)
WUTTKE WOLFGANG (DE)
JARRY HUBERTUS (DE)
POPP MICHAEL (DE)
CHRISTOFFEL VOLKER (DE)
SPENGLER BARBARA (DE)
International Classes:
A61K31/00; A61K31/045; A61K31/047; A61K31/22; A61K31/34; A61K31/341; A61K36/18; A61P5/08; A61P5/12; A61P15/00; C07C33/14; C07C35/36; C07D307/42; C07D307/46; C07D307/58; H04L29/06; (IPC1-7): A61K31/045; A61K31/34; A61K31/22
Domestic Patent References:
| WO1999063978A2 | 1999-12-16 | |||
| WO1996024684A1 | 1996-08-15 |
Other References:
SLIUTZ G; SPEISER P; SCHULTZ A M; SPONA J; ZEILLINGER R: "Agnus castus extracts inhibit prolactin secretion of rat pituitary cells", HORMONE AND METABOLIC RESEARCH, vol. 25, 1993, pages 253 - 255, XP000913717
MILEWICZ A; GEJDEL E; SWOREN H; SIENKIEWICZ K; JEDRZEJAK J; TEUCHER T; SCHMITZ H: "Vitex agnus castus extract in the treatment of luteal phase defects due to latent hyperprolactinaemia: Results of a randomized placebo-controlled double blind study.", ARZNEIMITTEL-FORSCHUNG, vol. 43, 1993, pages 752 - 756, XP000913700
JARRY H; LEONHARDT SABINE; GORKOW C; WUTTKE W: "In vitro prolactin but not LH and FSH release is inhibited by compounds in extracts of Agnus castus: Direct evidence for a dopaminergic principle by the dopamine receptor assay.", EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY, vol. 102, 1994, pages 448 - 454, XP000913581
HAN, BYUNG HOON ET AL: "In Vitro Platelet-Activating Factor Receptor Binding Inhibitory Activity of Pinusolide Derivatives: A Structure-Activity Study", J. MED. CHEM. (1998), 41(14), 2626-2630, 1998, XP000907424
CAHILL D J; FOX R; WARDLE P G; HARLOW C R: "Multiple follicular development associated with herbal medicine.", HUMAN REPRODUCTION (OXFORD), vol. 9, 1994, pages 1469 - 1470, XP000913660
TAGUCHI, HEIHACHIRO: "Studies on the constituents of Vitex cannabifolia", CHEM. PHARM. BULL. (1976), 24(7), 1668-70, XP000907422
KONDO Y ET AL: "STUDIES ON THE CONSTITUENTS OF VITEX-ROTUNDIFOLIA L. FIL.", CHEM PHARM BULL (TOKYO), (1986) 34 (11), 4829-4932., XP000907421
MALES Z; BLAZEVIC N: "Composition of the essential oil of Vitex agunus-castus L. f. rosea fruits.", PHARMAZIE, vol. 53, 1998, pages 728 - 729, XP000907423
OHSAKI, AYUMI ET AL: "The isolation and in vivo potent antitumor activity of clerodane diterpenoid from the oleoresin of the Brazilian medicinal plant, Copaifera langsdorfii Desfon", BIOORG. MED. CHEM. LETT. (1994), 4(24), 2889-92, 1994, XP000913600
CHEN, ZHENG-PING ET AL: "Studies on the antitumor, antibacterial, and wound-healing properties of dragon's blood", PLANTA MED. (1994), 60(6), 541-5, 1994, pages 1469 - 1470, XP000913598
ROJAS, A. ET AL: "Smooth muscle-relaxing compounds from Dodonaea viscosa", PLANTA MED., vol. 62, no. 2, 1996, pages 154 - 159, XP000913597
MILEWICZ A; GEJDEL E; SWOREN H; SIENKIEWICZ K; JEDRZEJAK J; TEUCHER T; SCHMITZ H: "Vitex agnus castus extract in the treatment of luteal phase defects due to latent hyperprolactinaemia: Results of a randomized placebo-controlled double blind study.", ARZNEIMITTEL-FORSCHUNG, vol. 43, 1993, pages 752 - 756, XP000913700
JARRY H; LEONHARDT SABINE; GORKOW C; WUTTKE W: "In vitro prolactin but not LH and FSH release is inhibited by compounds in extracts of Agnus castus: Direct evidence for a dopaminergic principle by the dopamine receptor assay.", EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY, vol. 102, 1994, pages 448 - 454, XP000913581
HAN, BYUNG HOON ET AL: "In Vitro Platelet-Activating Factor Receptor Binding Inhibitory Activity of Pinusolide Derivatives: A Structure-Activity Study", J. MED. CHEM. (1998), 41(14), 2626-2630, 1998, XP000907424
CAHILL D J; FOX R; WARDLE P G; HARLOW C R: "Multiple follicular development associated with herbal medicine.", HUMAN REPRODUCTION (OXFORD), vol. 9, 1994, pages 1469 - 1470, XP000913660
TAGUCHI, HEIHACHIRO: "Studies on the constituents of Vitex cannabifolia", CHEM. PHARM. BULL. (1976), 24(7), 1668-70, XP000907422
KONDO Y ET AL: "STUDIES ON THE CONSTITUENTS OF VITEX-ROTUNDIFOLIA L. FIL.", CHEM PHARM BULL (TOKYO), (1986) 34 (11), 4829-4932., XP000907421
MALES Z; BLAZEVIC N: "Composition of the essential oil of Vitex agunus-castus L. f. rosea fruits.", PHARMAZIE, vol. 53, 1998, pages 728 - 729, XP000907423
OHSAKI, AYUMI ET AL: "The isolation and in vivo potent antitumor activity of clerodane diterpenoid from the oleoresin of the Brazilian medicinal plant, Copaifera langsdorfii Desfon", BIOORG. MED. CHEM. LETT. (1994), 4(24), 2889-92, 1994, XP000913600
CHEN, ZHENG-PING ET AL: "Studies on the antitumor, antibacterial, and wound-healing properties of dragon's blood", PLANTA MED. (1994), 60(6), 541-5, 1994, pages 1469 - 1470, XP000913598
ROJAS, A. ET AL: "Smooth muscle-relaxing compounds from Dodonaea viscosa", PLANTA MED., vol. 62, no. 2, 1996, pages 154 - 159, XP000913597
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