Title:
Agent and method for reducing intraocular pressure
Document Type and Number:
WIPO Patent Application WO2001072776
Kind Code:
A3
Abstract:
A method for reducing cell contacts and matrix organization in trabecular meshwork of a human or nonhuman eye includes the step of administering a suitable peptide having a sequence found in the Hep II domain of fibronectin where the peptide has an ability to disrupt cell contacts and matrix formation. A result of the disruption is reduced intraocular pressure in the treated eye.
Inventors:
PETERS DONNA M (US)
KAUFMAN PAUL L (US)
KAUFMAN PAUL L (US)
Application Number:
PCT/US2001/010068
Publication Date:
April 25, 2002
Filing Date:
March 29, 2001
Export Citation:
Assignee:
WISCONSIN ALUMNI RES FOUND (US)
International Classes:
C07K14/78; C12N5/08; A61K38/00; (IPC1-7): C07K14/78; A61K38/39; A61P27/06
Foreign References:
| US6013628A | 2000-01-11 | |||
| US5019646A | 1991-05-28 |
Other References:
HOGG P ET AL.: "Migration of Cultured Bovine Meshwork Cells to Aqueous Humor and Constituents", INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, vol. 36, no. 12, November 1995 (1995-11-01), pages 2449 - 2460, XP001063998
YANG CH ET AL.: "Inhibition of Cell-Induced Vitreous Contraction by Synthetic Peptide Derived from the Collagen Receptor Binding Sequence", JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS, vol. 12, no. 3, 1996, pages 353 - 361, XP001053796
YANG CH ET AL.: "Inhibition of Cell-Induced Vitreous Contraction by Synthetic Peptide Derived from the Collagen Receptor Binding Sequence", JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS, vol. 12, no. 3, 1996, pages 353 - 361, XP001053796
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