Title:
AGENT FOR REDUCING VISCERAL FAT WEIGHT
Document Type and Number:
WIPO Patent Application WO/2011/037223
Kind Code:
A1
Abstract:
Disclosed is an FGF21 production enhancer which contains a compound represented by general formula (1), a salt thereof or a solvate of the compound or salt as an active ingredient.
(In the formula, R1 and R2 may be the same or different and each represents a hydrogen atom or the like; R3a, R3b, R4a and R4b may be the same or different and each represents a hydrogen atom, a halogen atom or the like, or R3a and R3b or R4a and R4b may combine together and represent an alkylenedioxy group; X represents an oxygen atom, a sulfur atom or an N-R5 group (wherein R5 represents a hydrogen atom, a C1-4 alkyl group or the like); Y represents an oxygen atom, an S(O)l group (wherein l represents a number of 0-2), a carbonyl group or the like; Z represents a CH group or N; n represent a number of 1-6; and m represents a number of 2-6.)
Inventors:
TAKIZAWA TOSHIAKI (JP)
MURAKAMI KENTARO (JP)
MURAKAMI KENTARO (JP)
Application Number:
PCT/JP2010/066678
Publication Date:
March 31, 2011
Filing Date:
September 27, 2010
Export Citation:
Assignee:
KOWA CO (JP)
TAKIZAWA TOSHIAKI (JP)
MURAKAMI KENTARO (JP)
TAKIZAWA TOSHIAKI (JP)
MURAKAMI KENTARO (JP)
International Classes:
A61K31/423; A61P3/04; A61P3/06; A61P9/00; A61P9/10; A61P13/12; A61P29/00; A61P43/00; C07D263/58
Domestic Patent References:
| WO2005023777A1 | 2005-03-17 | |||
| WO2008120472A1 | 2008-10-09 | |||
| WO2005023777A1 | 2005-03-17 | |||
| WO2009080248A1 | 2009-07-02 | |||
| WO2009047240A1 | 2009-04-16 | |||
| WO2008006043A2 | 2008-01-10 | |||
| WO2006049232A1 | 2006-05-11 | |||
| WO2006033891A2 | 2006-03-30 | |||
| WO2005009942A1 | 2005-02-03 | |||
| WO2004103997A1 | 2004-12-02 | |||
| WO2005097784A1 | 2005-10-20 | |||
| WO2003043997A1 | 2003-05-30 |
Foreign References:
| JP2006246823A | 2006-09-21 |
Other References:
MICHAEL K. BADMAN ET AL.: "Hepatic Fibroblast Growth Factor 21 Is Regulatedby PPARa and Is a Key Mediatorof Hepatic Lipid Metabolism in Ketotic States", CELL METABOLISM, vol. 5, 2007, pages 426 - 437, XP008151941
CECILIA GALMAN ET AL.: "The Circulating Metabolic RegulatorFGF21 Is Induced by Prolonged Fastingand PPARa Activation in Man", CELL METABOLISM, vol. 8, 2008, pages 169 - 174, XP008151936
TAKESHI INAGAKI ET AL.: "Endocrine Regulation of the Fasting Responseby PPARa-Mediated Inductionof Fibroblast Growth Factor 21", CELL METABOLISM, vol. 5, 2007, pages 415 - 425, XP008151942
THOMAS LUNDASEN ET AL.: "PPARa is a key regulator of hepatic FGF21", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 360, no. 2, 2007, pages 437 - 440, XP022145176
SADAO TAKAHASHI ET AL.: "Metabolic Syndrome no Kagi Bunshi PPARs", CARDIOANGIOLOGY, vol. 59, no. 2, 2006, pages 160 - 167, XP008153472
SHIZUYA YAMASHITA: "Metabolic Syndrome Kenkyu no Shinten Metabolic Syndrome no Chiryo Senryaku no Shinpo", NAIBUNPITSU-JUNKANKIKA, vol. 24, no. 5, 2007, pages 484 - 490, XP008151955
TOSHIMASA YAMAUCHI ET AL.: "Naizo Himan ni Taisuru Yakubutsu Chiryo", BESSATSU-IGAKU NO AYUMI NAFLD NO SUBETE, 5 March 2006 (2006-03-05), pages 144 - 149, XP008153469
MOTOKO UCHIYAMA ET AL.: "Ko Himan Koka Hyokakei no Kento - Ko Shiboshoku Sesshu Oyobi PPARa Agonist ga KK-Ay Mouse ni Ataeru Eikyo", DAI 61 KAI THE JAPANESE SOCIETY OF NUTRITION AND FOOD SCIENCE TAIKAI KOEN YOSHISHU, 20 April 2007 (2007-04-20), pages 204, XP008151954
MASAKI TSUNODA ET AL.: "A novel PPARa agonist ameliorates insulin resistance in dogs feda high-fat diet", AMERICAN JOURNAL OF PHYSIOLOGY. ENDOCRINOLOGY AND METABOLISM, vol. 294, 2008, pages E833 - E840, XP008151952
IKUO IKEDA ET AL.: "Campest-5-en-3-one, an oxidized derivative of campesterol, activates PPARa, promotes energy consumption and reduces visceral fat deposition in rats", BIOCHIMICA ET BIOPHYSICA ACTA, vol. 1760, 2006, pages 800 - 807, XP025015031
J. LIPID RESEARCH, vol. 37, 1996, pages 907 - 925
TRENDS IN ENDOCLINOLOGY METABOLISM, vol. 15, 2004, pages 324 - 330
GENOME BIOL., vol. 21, 2001, pages 3005
TRENDS GENET., vol. 20, 2004, pages 563 - 569
BIOCHIM. BIOPHYS. ACTA, vol. 1492, 2000, pages 203 - 206
BIODRUGS, vol. 22, no. 1, 2008, pages 37 - 44
EMBO REP., vol. 7, 2006, pages 649 - 54
CELL METABOLISM, vol. 8, 2008, pages 169 - 174
J. PHARMACOL. THER., vol. 23, 1995, pages 15 - 36
DIABETES, vol. 58, 2009, pages 250 - 259
J. CLIN. INVEST., vol. 115, 2005, pages 1627 - 1635
"Diabetes", vol. 52, 2009, THE 24TH ANNUAL MEETING OF JAPAN DIABETES SOCIETY, pages: S-157
FASEB J., vol. 20, 2006, pages 1203 - 1205
CECILIA GALMAN ET AL.: "The Circulating Metabolic RegulatorFGF21 Is Induced by Prolonged Fastingand PPARa Activation in Man", CELL METABOLISM, vol. 8, 2008, pages 169 - 174, XP008151936
TAKESHI INAGAKI ET AL.: "Endocrine Regulation of the Fasting Responseby PPARa-Mediated Inductionof Fibroblast Growth Factor 21", CELL METABOLISM, vol. 5, 2007, pages 415 - 425, XP008151942
THOMAS LUNDASEN ET AL.: "PPARa is a key regulator of hepatic FGF21", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 360, no. 2, 2007, pages 437 - 440, XP022145176
SADAO TAKAHASHI ET AL.: "Metabolic Syndrome no Kagi Bunshi PPARs", CARDIOANGIOLOGY, vol. 59, no. 2, 2006, pages 160 - 167, XP008153472
SHIZUYA YAMASHITA: "Metabolic Syndrome Kenkyu no Shinten Metabolic Syndrome no Chiryo Senryaku no Shinpo", NAIBUNPITSU-JUNKANKIKA, vol. 24, no. 5, 2007, pages 484 - 490, XP008151955
TOSHIMASA YAMAUCHI ET AL.: "Naizo Himan ni Taisuru Yakubutsu Chiryo", BESSATSU-IGAKU NO AYUMI NAFLD NO SUBETE, 5 March 2006 (2006-03-05), pages 144 - 149, XP008153469
MOTOKO UCHIYAMA ET AL.: "Ko Himan Koka Hyokakei no Kento - Ko Shiboshoku Sesshu Oyobi PPARa Agonist ga KK-Ay Mouse ni Ataeru Eikyo", DAI 61 KAI THE JAPANESE SOCIETY OF NUTRITION AND FOOD SCIENCE TAIKAI KOEN YOSHISHU, 20 April 2007 (2007-04-20), pages 204, XP008151954
MASAKI TSUNODA ET AL.: "A novel PPARa agonist ameliorates insulin resistance in dogs feda high-fat diet", AMERICAN JOURNAL OF PHYSIOLOGY. ENDOCRINOLOGY AND METABOLISM, vol. 294, 2008, pages E833 - E840, XP008151952
IKUO IKEDA ET AL.: "Campest-5-en-3-one, an oxidized derivative of campesterol, activates PPARa, promotes energy consumption and reduces visceral fat deposition in rats", BIOCHIMICA ET BIOPHYSICA ACTA, vol. 1760, 2006, pages 800 - 807, XP025015031
J. LIPID RESEARCH, vol. 37, 1996, pages 907 - 925
TRENDS IN ENDOCLINOLOGY METABOLISM, vol. 15, 2004, pages 324 - 330
GENOME BIOL., vol. 21, 2001, pages 3005
TRENDS GENET., vol. 20, 2004, pages 563 - 569
BIOCHIM. BIOPHYS. ACTA, vol. 1492, 2000, pages 203 - 206
BIODRUGS, vol. 22, no. 1, 2008, pages 37 - 44
EMBO REP., vol. 7, 2006, pages 649 - 54
CELL METABOLISM, vol. 8, 2008, pages 169 - 174
J. PHARMACOL. THER., vol. 23, 1995, pages 15 - 36
DIABETES, vol. 58, 2009, pages 250 - 259
J. CLIN. INVEST., vol. 115, 2005, pages 1627 - 1635
"Diabetes", vol. 52, 2009, THE 24TH ANNUAL MEETING OF JAPAN DIABETES SOCIETY, pages: S-157
FASEB J., vol. 20, 2006, pages 1203 - 1205
Attorney, Agent or Firm:
THE PATENT CORPORATE BODY ARUGA PATENT OFFICE (JP)
Patent business corporation Alga patent firm (JP)
Patent business corporation Alga patent firm (JP)
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