Title:
ALIPHATIC COMPOUND-CONTAINING SKIN WHITENING AGENT
Document Type and Number:
WIPO Patent Application WO/2008/047633
Kind Code:
A1
Abstract:
Disclosed is a skin whitening agent having excellent skin whitening effect,
while having high safety to the human body and high melanin production inhibiting
effect. Specifically disclosed is a skin whitening agent characterized by containing
an aliphatic compound represented by the formula I below, a stereoisomer thereof,
an optical isomer thereof, or a pharmaceutically acceptable salt of any of them.
[chemical formula 1] I (In the formula, R represents a hydrogen or a C1-10
linear or branched alkyl group; and R' represents a hydrogen or a C1-10
linear or branched alkyl group, or alternatively OR' is combined to form
a carbonyl group.)
Inventors:
TAMAI TADAKAZU (JP)
OKADA TSUYOSHI (JP)
MUROTA ITSUKI (JP)
OKADA TSUYOSHI (JP)
MUROTA ITSUKI (JP)
Application Number:
PCT/JP2007/069699
Publication Date:
April 24, 2008
Filing Date:
October 09, 2007
Export Citation:
Assignee:
MARUHA CORP (JP)
TAMAI TADAKAZU (JP)
OKADA TSUYOSHI (JP)
MUROTA ITSUKI (JP)
TAMAI TADAKAZU (JP)
OKADA TSUYOSHI (JP)
MUROTA ITSUKI (JP)
International Classes:
A61K8/365; A61K8/37; A61K31/202; A61K31/232; A61P17/00; A61P17/16; A61P43/00; A61Q19/02
Domestic Patent References:
| WO2002102364A1 | 2002-12-27 | |||
| WO2005115324A1 | 2005-12-08 |
Foreign References:
| JPH0193520A | 1989-04-12 | |||
| JPH03209305A | 1991-09-12 | |||
| JPH06157284A | 1994-06-03 |
Other References:
YAMAMOTO ET AL.: "Identification of putative metabolites of docosahexaenoic acid as potent PPARgamma agonists and antidiabetic agents", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 15, 2005, pages 517 - 522, XP004719959
ITOH ET AL.: "Synthesis of docosahexaenoic acid derivatives designed as novel PPARgamma agonists and antidiabetic agents", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 14, 2006, pages 98 - 108, XP005168791
WIECHERS ET AL.: "A new mechanism of action for skin whitening agents: binding to the peroxisome proliferator-activated receptor", INT. J. COSMETIC SCIENCE, vol. 27, 2005, pages 123 - 132, XP002556631, DOI: doi:10.1111/j.1467-2494.2004.00256.x
ITOH ET AL.: "Synthesis of docosahexaenoic acid derivatives designed as novel PPARgamma agonists and antidiabetic agents", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 14, 2006, pages 98 - 108, XP005168791
WIECHERS ET AL.: "A new mechanism of action for skin whitening agents: binding to the peroxisome proliferator-activated receptor", INT. J. COSMETIC SCIENCE, vol. 27, 2005, pages 123 - 132, XP002556631, DOI: doi:10.1111/j.1467-2494.2004.00256.x
Attorney, Agent or Firm:
SHAMOTO, Ichio et al. (Section 206 New Ohtemachi Bldg., 2-1, Ohtemachi 2-chome, Chiyoda-k, Tokyo 04, JP)
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