Title:
AMELIORATION OF ISCHEMIC DAMAGE USING SYNTHETIC OXYGEN CARRIERS
Document Type and Number:
WIPO Patent Application WO1999021541
Kind Code:
A3
Abstract:
A method of ameliorating tissue damage resulting from hypoxia or ischemia by administering systematically a synthetic oxygen carrier to an individual having or suspected of having blood vessel obstruction is disclosed. A synthetic oxygen carrier in a physiologically acceptable vehicle, wherein the synthetic oxygen carrier comprises submicron sized particles capable of passing through emboli-obstructed blood vessels is also disclosed. The synthetic oxygen carrier is preferably a fluorocarbon emulsion, crystalloid blood substitute, a colloid blood substitute, or a combination thereof.
Inventors:
KEIPERT PETER E (US)
FAITHFULL N SIMON (US)
FLAIM STEPHEN F (US)
ROSENBERG GWEN H (US)
FAITHFULL N SIMON (US)
FLAIM STEPHEN F (US)
ROSENBERG GWEN H (US)
Application Number:
PCT/US1998/022491
Publication Date:
August 05, 1999
Filing Date:
October 23, 1998
Export Citation:
Assignee:
ALLIANCE PHARMA (US)
KEIPERT PETER E (US)
FAITHFULL N SIMON (US)
FLAIM STEPHEN F (US)
ROSENBERG GWEN H (US)
KEIPERT PETER E (US)
FAITHFULL N SIMON (US)
FLAIM STEPHEN F (US)
ROSENBERG GWEN H (US)
International Classes:
A61K31/02; A61K31/428; A61K38/18; (IPC1-7): A61K31/02
Domestic Patent References:
| WO1992010221A2 | 1992-06-25 | |||
| WO1996040057A2 | 1996-12-19 |
Foreign References:
| EP0037992A1 | 1981-10-21 | |||
| US5085630A | 1992-02-04 | |||
| EP0088954A2 | 1983-09-21 |
Other References:
SYMONS, J. D. ET AL: "Perflubron emulsion increases tolerance to myocardial ischemia in the isolated rabbit heart.", FASEB JOURNAL, (1995) VOL. 9, NO. 3, PP. A622. MEETING INFO.: EXPERIMENTAL BIOLOGY 95, PART I ATLANTA, GEORGIA, USA APRI 9-13, 1995 ISSN: 0892-6638., XP002104378
HALE, S. L. ET AL: "Effect of two perfluorocarbon emulsions on reperfusion injury after coronary artery occlusion in rabbits", BASIC RES. CARDIOL. (1995), VOLUME DATE 1995, 90(5), 404-9 CODEN: BRCAB7;ISSN: 0300-8428, XP002104379
MOSCA R S ET AL: "Perfluorocarbon supplementation and postischemic cardiac function.", SURGERY, (1996 AUG) 120 (2) 197-204. JOURNAL CODE: VC3. ISSN: 0039-6060., United States, XP002104380
DEL BALZO, U. ET AL: "Perflubron emulsion: Effect on post- ischemic ventricular function in the isolated rabbit heart.", JOURNAL OF INVESTIGATIVE MEDICINE, (1996) VOL. 44, NO. 7, PP. 415A. MEETING INFO.: MEETING OF THE EASTERN SECTION OF THE AMERICAN FEDERATION FOR CLINICAL RESEARCH BOSTON, MASSACHUSETTS, USA OCTOBER 4-5, 1996 ISSN: 1081-5589., XP002104381
VOIGLIO, ERIC J. ET AL: "Aerobic preservation of organs using a new perflubron /lecithin emulsion stabilized by molecular dowels", J. SURG. RES. (1996), 63(2), 439-446 CODEN: JSGRA2;ISSN: 0022-4804, XP002104382
HALE, S. L. ET AL: "Effect of two perfluorocarbon emulsions on reperfusion injury after coronary artery occlusion in rabbits", BASIC RES. CARDIOL. (1995), VOLUME DATE 1995, 90(5), 404-9 CODEN: BRCAB7;ISSN: 0300-8428, XP002104379
MOSCA R S ET AL: "Perfluorocarbon supplementation and postischemic cardiac function.", SURGERY, (1996 AUG) 120 (2) 197-204. JOURNAL CODE: VC3. ISSN: 0039-6060., United States, XP002104380
DEL BALZO, U. ET AL: "Perflubron emulsion: Effect on post- ischemic ventricular function in the isolated rabbit heart.", JOURNAL OF INVESTIGATIVE MEDICINE, (1996) VOL. 44, NO. 7, PP. 415A. MEETING INFO.: MEETING OF THE EASTERN SECTION OF THE AMERICAN FEDERATION FOR CLINICAL RESEARCH BOSTON, MASSACHUSETTS, USA OCTOBER 4-5, 1996 ISSN: 1081-5589., XP002104381
VOIGLIO, ERIC J. ET AL: "Aerobic preservation of organs using a new perflubron /lecithin emulsion stabilized by molecular dowels", J. SURG. RES. (1996), 63(2), 439-446 CODEN: JSGRA2;ISSN: 0022-4804, XP002104382
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