Title:
METHODS FOR MODULATING MACROPHAGE PROLIFERATION USING POLYAMINE ANALOGS
Document Type and Number:
WIPO Patent Application WO1999021542
Kind Code:
A3
Abstract:
Methods for modulating macrophage proliferation in an individual afflicted wiht or at risk for a macrophage-associated disease are provided. The methods employ a polyamine analog, or salt or protected derivative thereof. Macrophage proliferation has been implicated in a number of serious disorders, including AIDS (HIV)-associated dementia, AIDS-associated non-Hodgkin's lymphoma, and Alzheimer's disease. The invention also provides methods for aiding diagnosis and monitoring therapy of a macrophage-associated non-HIV associated dementia, especially Alzheimer's disease. The invention also provides methods of delaying development of macrophage-associated non-HIV associated dementias, including Alzheimer's disease, which entail administration of an agent which modulates macrophage proliferation.
Inventors:
MCGRATH MICHAEL S (US)
Application Number:
PCT/US1998/022747
Publication Date:
January 20, 2000
Filing Date:
October 27, 1998
Export Citation:
Assignee:
UNIV CALIFORNIA (US)
MCGRATH MICHAEL S (US)
MCGRATH MICHAEL S (US)
International Classes:
A61K31/132; A61K31/13; A61K31/131; A61K31/155; A61P25/28; A61P43/00; G01N33/50; G01N33/569; G01N33/68; (IPC1-7): A61K31/13; A61K31/155; G01N33/569
Domestic Patent References:
| WO1996004019A1 | 1996-02-15 | |||
| WO1993014782A1 | 1993-08-05 | |||
| WO1992013548A1 | 1992-08-20 | |||
| WO1999003823A2 | 1999-01-28 | |||
| WO1993004036A1 | 1993-03-04 |
Foreign References:
| EP0436332A2 | 1991-07-10 | |||
| EP0399519A2 | 1990-11-28 | |||
| US5886051A | 1999-03-23 |
Other References:
L.MESSINA ET AL.: "Polyamine involvement in functional activation of human macrophages", J. LEUKOC. BIOL., vol. 52, no. 6, December 1992 (1992-12-01), pages 585 - 587, XP002102429
L. KACZMAREK ET AL.: "Inhibitors of Polyamine Biosynthesis Block Tumor Necrosis Factor-induced Activation of Macrophages", CANCER RES., vol. 52, no. 7, 1 April 1992 (1992-04-01), pages 1891 - 1894, XP002102430
M. MASCOLINI: "Oncologists Scout New Directions for KS and Lymphoma Therapies", J. INT. ASSOC. PHYSICIANS AIDS CARE, vol. 1, no. 5, June 1995 (1995-06-01), pages 10 - 14, XP002102431
S.W. LIM ET AL.: "MGBG THERAPY OF RELAPSED EXTRALYMPHATIC HIV-ASSOCIATED NON-HODGKIN'S LYMPHOMA (HIV NHL)", PROC. ANNU. MEET. AM. SOC. CLIN. ONCOL., vol. 14, March 1995 (1995-03-01), pages A1274, XP002102432
S.A. MILES: "CURATIVE THERAPY FOR AIDS CANCERS", INT. CONF. AIDS, vol. 11, no. 1, July 1996 (1996-07-01), pages 28, XP002102433
L.C.PENNING ET AL.: "SENSITIZATION OF TNF-INDUCED APOPTOSIS WITH POLYAMINE SYNTHESIS INHIBITORS IN DIFFERENT HUMAN AND MURINE TUMOUR CELL LINES", CYTOKINE, vol. 10, no. 6, June 1998 (1998-06-01), pages 423 - 431, XP002102434
MEIJI SEIKA CO.: "JP-A-08217670", DIALOG (R) FILE 399: CA SEARCH (R): 125 (25) 317383E, 27 August 1996 (1996-08-27), XP002115007
H.-G. BERNSTEIN ET AL.: "The cellular localization of the L-ornithine decarboxylase/polyamine system in normal and diseased central nervous systems", DIALOG (R) FILE 73: EMBASE, ACCESSION NUMBER 07638420: PROGRESS IN NEUROBIOLOGY, vol. 57, no. 5, 1999, pages 485 - 505, XP002115008
P.K. CHIANG ET AL.: "Antihuman immunodeficiency virus (HIV-1) activities of inhibitors of polyamine pathways", DIALOG (R) FILE 399: CA SEARCH (R), ACCESSION NUMBER 125 (13) 157800H: J. BIOMED. SCI., vol. 3, no. 2, 1996, pages 78 - 81, XP002115009
L. KACZMAREK ET AL.: "Inhibitors of Polyamine Biosynthesis Block Tumor Necrosis Factor-induced Activation of Macrophages", CANCER RES., vol. 52, no. 7, 1 April 1992 (1992-04-01), pages 1891 - 1894, XP002102430
M. MASCOLINI: "Oncologists Scout New Directions for KS and Lymphoma Therapies", J. INT. ASSOC. PHYSICIANS AIDS CARE, vol. 1, no. 5, June 1995 (1995-06-01), pages 10 - 14, XP002102431
S.W. LIM ET AL.: "MGBG THERAPY OF RELAPSED EXTRALYMPHATIC HIV-ASSOCIATED NON-HODGKIN'S LYMPHOMA (HIV NHL)", PROC. ANNU. MEET. AM. SOC. CLIN. ONCOL., vol. 14, March 1995 (1995-03-01), pages A1274, XP002102432
S.A. MILES: "CURATIVE THERAPY FOR AIDS CANCERS", INT. CONF. AIDS, vol. 11, no. 1, July 1996 (1996-07-01), pages 28, XP002102433
L.C.PENNING ET AL.: "SENSITIZATION OF TNF-INDUCED APOPTOSIS WITH POLYAMINE SYNTHESIS INHIBITORS IN DIFFERENT HUMAN AND MURINE TUMOUR CELL LINES", CYTOKINE, vol. 10, no. 6, June 1998 (1998-06-01), pages 423 - 431, XP002102434
MEIJI SEIKA CO.: "JP-A-08217670", DIALOG (R) FILE 399: CA SEARCH (R): 125 (25) 317383E, 27 August 1996 (1996-08-27), XP002115007
H.-G. BERNSTEIN ET AL.: "The cellular localization of the L-ornithine decarboxylase/polyamine system in normal and diseased central nervous systems", DIALOG (R) FILE 73: EMBASE, ACCESSION NUMBER 07638420: PROGRESS IN NEUROBIOLOGY, vol. 57, no. 5, 1999, pages 485 - 505, XP002115008
P.K. CHIANG ET AL.: "Antihuman immunodeficiency virus (HIV-1) activities of inhibitors of polyamine pathways", DIALOG (R) FILE 399: CA SEARCH (R), ACCESSION NUMBER 125 (13) 157800H: J. BIOMED. SCI., vol. 3, no. 2, 1996, pages 78 - 81, XP002115009
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