Title:
ANTIBODY CAPABLE OF BINDING TO TROP2, AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/143670
Kind Code:
A1
Abstract:
Provided is an isolated monoclonal antibody capable of specifically binding to Trop2. Also provided are a nucleic acid molecule encoding the antibody, an expression vector for expressing the antibody, a host cell, and a method. Further provided are an immunoconjugate, a bispecific molecule, a chimeric antigen receptor, an oncolytic virus, and a pharmaceutical composition containing the antibody, and a diagnostic or therapeutic method using the antibody.
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Inventors:
LV QIANG (CN)
HUANG BING (CN)
RONG YIPING (CN)
HUANG BING (CN)
RONG YIPING (CN)
Application Number:
PCT/CN2021/142095
Publication Date:
July 07, 2022
Filing Date:
December 28, 2021
Export Citation:
Assignee:
HARBOUR BIOMED SUZHOU CO LTD (CN)
International Classes:
C07K16/30; A61K39/00; A61K39/395; C07K16/00; C12P21/08
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LIN, HONG; LIANG, JIE; ZHANG, HUILIN; TANG, QI; SU, YIPING; CAO, BRIAN; ZHU, JIN; GUAN, XIAOHONG: "Preparation and characterization of human anti-Trop-2 engineering antibody Fab", SHENGWU HUAXUE YU SHENGWU WULI JINZHAN - BIOCHEMISTRY AND BIOPHYSICS, KEXUE CHUBANSHE, BEIJING, CN, vol. 37, no. 10, 1 January 2010 (2010-01-01), CN , pages 1101 - 1107, XP009512198, ISSN: 1000-3282, DOI: 10.3724/SP.J.1206.2010.00211
"Genbank", Database accession no. XP_005543292.1
BRUMMELL ET AL., BIOCHEM, vol. 32, 1993, pages 1180 - 8
WILDT ET AL., PROT. ENG., vol. 10, 1997, pages 835 - 41
KOMISSAROV ET AL., J. BIOL. CHEM., vol. 272, 1997, pages 26864 - 26870
HALL ET AL., J. IMMUNOL., vol. 149, 1992, pages 1605 - 12
KELLEY AND O'CONNELL, BIOCHEM., vol. 32, 1993, pages 6862 - 35
ADIB-CONQUY ET AL., INT. IMMUNOL., vol. 10, 1998, pages 341 - 6
BEERS ET AL., CLIN. CAN. RES., vol. 6, 2000, pages 2835 - 43
RIECHMANN ET AL., NATURE, vol. 332, 1998, pages 323 - 327
JONES ET AL., NATURE, vol. 321, 1986, pages 522 - 525
QUEEN ET AL., PROC. NATL. ACAD; U.S.A., vol. 86, 1989, pages 10029 - 10033
TOMLINSON ET AL., J. MOL. BIOL., vol. 227, 1992, pages 776 - 798
COX, EUR. J. IMMUNOL., vol. 24, 1994, pages 827 - 836
YAMANE-OHNUKI ET AL., BIOTECHNOL BIOENG, vol. 87, 2004, pages 614 - 22
SHIELD ET AL., J. BIOL. CHEM., vol. 277, 2002, pages 26733 - 26740
UMANA ET AL., NAT. BIOTECH., vol. 17, 1999, pages 176 - 180
TARENTINO ET AL., BIOCHEM., vol. 14, 1975, pages 5516 - 23
MARSHALL ET AL., ANNU REV BIOCHEM., vol. 41, 1972, pages 673 - 702
GALAMORRISON, J IMMUNOL., vol. 172, 2004, pages 5489 - 94
WALLICK ET AL., J EXP MED., vol. 168, 1988, pages 1099 - 109
SPIRO, GLYCOBIOLOGY, vol. 12, 2002, pages 43 - 56
PAREKH ET AL., NATURE, vol. 316, 1985, pages 452 - 7
2000, MOL IMMUNOL., vol. 37, pages 697 - 706
BIRD ET AL., SCIENCE, vol. 242, 1988, pages 423 - 426
HUSTON ET AL., PROC. NATL. ACAD. SCI. USA, vol. 85, 1988, pages 5879 - 5883
MCCAFFERTY ET AL., NATURE, vol. 348, 1990, pages 552 - 554
KOHLERMILSTEIN, NATURE, vol. 256, 1975, pages 495
MORRISON, S., SCIENCE, vol. 229, 1985, pages 1202
"Goeddel", vol. 185, 1990, ACADEMIC PRESS, article "Gene Expression Technology. Methods in Enzymology"
TAKEBE ET AL., MOL. CELL. BIOL., vol. 8, 1988, pages 466 - 472
PROC. NATL. ACAD. SCI. USA, vol. 77, 1980, pages 4216 - 4220
R. J. KAUFMANP. A. SHARP, J. MOL. BIOL., vol. 159, 1982, pages 601 - 621
CAOSURESH, BIOCONJUGATE CHEMISTRY,, vol. 9, no. 6, 1998, pages 635 - 644
SPRIEL ET AL., IMMUNOLOGY TODAY, vol. 21, no. 8, 2000, pages 391 - 397
"Remington: The Science and Practice of harmacy", 2003, LIPPINCOTT WILLIAMS & WILKINS
"Sustained and Controlled Release Drug Delivery Systems", 1978, MARCEL DEKKER, INC.
V. V. RANADE, J. CLIN.PHARMACOL, vol. 29, 1989, pages 685
UMEZAWA ET AL., BIOCHEM. BIOPHYS. RES. COMMUN., vol. 153, 1988, pages 1038
BLOEMAN ET AL., FEBS LETT., vol. 357, 1995, pages 140
M. OWAIS ET AL., ANTIMICROB. AGENTS CHEMOTHER., vol. 39, 1995, pages 180
BRISCOE ET AL., AM. J. PHYSIOL., vol. 1233, 1995, pages 134
SCHREIER ET AL., J. BIOL. CHEM., vol. 269, 1994, pages 9090
KEINANENLAUKKANEN, FEBS LETT., vol. 346, 1994, pages 123
KILLIONFIDLER, IMMUNOMETHODS, vol. 4, 1994, pages 273
SAMBROOK ET AL.: "Molecular Cloning: Laboratory Manual", 1989, COLD SPRING HARBOR LABORATORY PRESS
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