Title:
APPLICATION OF ITF2357 IN PREPARATION OF DRUG FOR PREVENTING AND TREATING CORONAVIRUSES
Document Type and Number:
WIPO Patent Application WO/2022/088047
Kind Code:
A1
Abstract:
Provided is an application of ITF2357 in the preparation of a drug for preventing and treating coronaviruses. Disclosed are the use of ITF2357 in the preparation of a drug for preventing and treating coronaviruses, and the use of ITF2357 or pharmaceutically acceptable salts, isotopes, stereoisomers, mixtures of stereoisomers, tautomers, esters, amides, or prodrugs thereof in the preparation of a drug for preventing and/or treating diseases caused by coronaviruses. The coronaviruses are the novel coronaviruses SARS-Cov-2, SARS-CoV, HCoV 229E, NL63, OC43, HKU1, and MERS-CoV. The diseases caused by coronaviruses are pneumonia, or complications thereof, caused by SARS-CoV-2, SARS-COV, HCoV 229E, NNL 63, OC 43, HKU1, or MERS-COV. For the first time, ITF2357 has been confirmed to have an inhibitory effect on novel coronavirus, is low in half effective concentration, and has significant potential.
Inventors:
YUAN SHUGUANG (CN)
LI HONGCHANG (CN)
ZOU RONGFENG (CN)
CUI WENQIANG (CN)
LIU KE (CN)
LI HONGCHUN (CN)
CHEN XIANCHONG (CN)
LI HONGCHANG (CN)
ZOU RONGFENG (CN)
CUI WENQIANG (CN)
LIU KE (CN)
LI HONGCHUN (CN)
CHEN XIANCHONG (CN)
Application Number:
PCT/CN2020/125280
Publication Date:
May 05, 2022
Filing Date:
October 30, 2020
Export Citation:
Assignee:
SHENZHEN INST OF ADV TECH CAS (CN)
International Classes:
A61K31/325; A61K31/167; A61P11/00; A61P31/14
Domestic Patent References:
| WO2011113013A2 | 2011-09-15 | |||
| WO2016063251A1 | 2016-04-28 | |||
| WO2004065355A1 | 2004-08-05 |
Foreign References:
| CN102548551A | 2012-07-04 |
Other References:
TEODORI LAURA, SESTILI PIERO, MADIAI VALERIA, COPPARI SOFIA, FRATERNALE DANIELE, ROCCHI MARCO BRUNO LUIGI, RAMAKRISHNA SEERAM, ALB: "Pathways and microRNAs bioinformatics analyses identifying possible existing therapeutics for COVID-19 treatment", RESEARCH SQUARE., 16 May 2020 (2020-05-16), pages 1 - 19, XP055927152, DOI: 10.21203/rs.3.rs-29446/v1
MILAZZO GIORGIO, MERCATELLI DANIELE, DI MUZIO GIULIA, TRIBOLI LUCA, DE ROSA PIERGIUSEPPE, PERINI GIOVANNI, GIORGI FEDERICO M.: "Histone Deacetylases (HDACs): Evolution, Specificity, Role in Transcriptional Complexes, and Pharmacological Actionability", GENES, vol. 11, no. 556, 15 May 2020 (2020-05-15), pages 1 - 49, XP055927158, DOI: 10.3390/genes11050556
MILAZZO GIORGIO, MERCATELLI DANIELE, DI MUZIO GIULIA, TRIBOLI LUCA, DE ROSA PIERGIUSEPPE, PERINI GIOVANNI, GIORGI FEDERICO M.: "Histone Deacetylases (HDACs): Evolution, Specificity, Role in Transcriptional Complexes, and Pharmacological Actionability", GENES, vol. 11, no. 556, 15 May 2020 (2020-05-15), pages 1 - 49, XP055927158, DOI: 10.3390/genes11050556
Attorney, Agent or Firm:
BEIJING CHENGHUI LAW FIRM (CN)
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