BIOMOLECULE STRUCTURE DETECTION PROBE, BIOMOLECULE STRUCTURE DETECTION KIT, AND METHOD FOR DETECTING BIOMOLECULE STRUCTURE

WIPO Patent Application WO/2022/118862

A1

Provided is a biomolecule structure detection probe in which a marker substance and a specific bonding substance that has specific bonding properties with respect to a biomolecule structure are connected via a linker that includes a disulfide bond. Also provided is a biomolecule structure detection kit including the aforementioned biomolecule structure detection probe and a reagent for severing the disulfide bond. Also provided is a biomolecule structure detection kit including: a linker for connecting a marker substance and a specific bonding substance that has specific bonding properties with respect to a biomolecule structure, the linker including a disulfide bond; a marker substance that can bond to the linker; and a reagent for severing the disulfide bond. Also provided is a method for detecting a biomolecule structure, the method involving using the aforementioned biomolecule structure detection probe.

OHKAWA YASUYUKI (JP)
TOMIMATSU KOSUKE (JP)

PCT/JP2021/043986

June 09, 2022

November 30, 2021

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UNIV KYUSHU NAT UNIV CORP (JP)

G01N33/536; C07K16/18

JPS6324155A	1988-02-01
JP2005511058A	2005-04-28
JP2007312776A	2007-12-06
JP2016525344A	2016-08-25
US20040259164A1	2004-12-23
JP2020199800A	2020-12-17
JP2018523826W

CAULUM MEGHAN M., MURPHY BRIAN M., RAMSAY LAUREN M., HENRY CHARLES S.: "Detection of Cardiac Biomarkers Using Micellar Electrokinetic Chromatography and a Cleavable Tag Immunoassay", ANALYTICAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 79, no. 14, 1 July 2007 (2007-07-01), US , pages 5249 - 5256, XP055936698, ISSN: 0003-2700, DOI: 10.1021/ac070452v

TANAI Sumio et al. (JP)

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