Title:
BIOSENSING PLATFORM FOR DETECTING VIRAL INFECTIONS AND METHODS FOR SCREENING A MODULATOR OF VIRAL INFECTIONS AND PROTECTING THEREFROM
Document Type and Number:
WIPO Patent Application WO/2022/083644
Kind Code:
A1
Abstract:
Provided is a method for screening a modulator of a viral infection by detecting an interaction of angiotensin converting enzyme 2 (ACE2) and a spike protein with a biosensing platform. Also provided is a compound of formula (I) as a modulator of a viral infection, where R, X, A, R 3 to R 5, and m are as defined herein, and a method for protecting a subject from a viral infection by administering with the compound.
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Inventors:
CHANG CHIA-CHING (CN)
SHIEH DAR-BIN (CN)
CHANG CHIA-YU (CN)
KIEW LIK VOON (MY)
HEH CHOON-HAN (MY)
LEO BEY-FEN (MY)
CHUNG LIP-YONG (MY)
SHIEH DAR-BIN (CN)
CHANG CHIA-YU (CN)
KIEW LIK VOON (MY)
HEH CHOON-HAN (MY)
LEO BEY-FEN (MY)
CHUNG LIP-YONG (MY)
Application Number:
PCT/CN2021/125021
Publication Date:
April 28, 2022
Filing Date:
October 20, 2021
Export Citation:
Assignee:
PD BIOMEDICAL CO LTD (CN)
International Classes:
G01N27/327; A61P31/12
Domestic Patent References:
| WO2006122819A1 | 2006-11-23 | |||
| WO2018234560A1 | 2018-12-27 |
Foreign References:
| CN103197054A | 2013-07-10 |
Other References:
KIEW LIK-VOON, CHANG CHIA-YU, HUANG SHENG-YU, WANG PEI-WEN, HEH CHOON-HAN, LIU CHUNG-TE, CHENG CHIA-HSIN, LU YI-XIANG, CHEN YEN-CH: "Development of flexible electrochemical impedance spectroscopy-based biosensing platform for rapid screening of SARS-CoV-2 inhibitors", BIOSENSORS AND BIOELECTRONICS, ELSEVIER SCIENCE LTD, UK, AMSTERDAM , NL, vol. 183, 1 July 2021 (2021-07-01), Amsterdam , NL , pages 113213, XP055912291, ISSN: 0956-5663, DOI: 10.1016/j.bios.2021.113213
RASHED MOHAMED Z.; KOPECHEK JONATHAN A.; PRIDDY MARIAH C.; HAMORSKY KRYSTAL T.; PALMER KENNETH E.; MITTAL NIKHIL; VALDEZ JOSEPH; F: "Rapid detection of SARS-CoV-2 antibodies using electrochemical impedance-based detector", BIOSENSORS AND BIOELECTRONICS, ELSEVIER SCIENCE LTD, UK, AMSTERDAM , NL, vol. 171, 7 October 2020 (2020-10-07), Amsterdam , NL , XP086320212, ISSN: 0956-5663, DOI: 10.1016/j.bios.2020.112709
HANSON QUINLIN M., WILSON KELLI M., SHEN MIN, ITKIN ZINA, EASTMAN RICHARD T., SHINN PAUL, HALL MATTHEW D.: "Targeting ACE2–RBD Interaction as a Platform for COVID-19 Therapeutics: Development and Drug-Repurposing Screen of an AlphaLISA Proximity Assay", ACS PHARMACOLOGY & TRANSLATIONAL SCIENCE, vol. 3, no. 6, 11 December 2020 (2020-12-11), pages 1352 - 1360, XP055868242, ISSN: 2575-9108, DOI: 10.1021/acsptsci.0c00161
LIU YINGXIA, HUANG FENGMING, XU JUN, YANG PENGHUI, QIN YUHAO, CAO MENGLI, WANG ZHAOQIN, LI XIAOHE, ZHANG SHAOGENG, YE LU, LV JINGJ: "Anti-hypertensive Angiotensin II receptor blockers associated to mitigation of disease severity in elderly COVID-19 patients", MEDRXIV, 27 March 2020 (2020-03-27), XP055923141, Retrieved from the Internet DOI: 10.1101/2020.03.20.20039586
RASHED MOHAMED Z.; KOPECHEK JONATHAN A.; PRIDDY MARIAH C.; HAMORSKY KRYSTAL T.; PALMER KENNETH E.; MITTAL NIKHIL; VALDEZ JOSEPH; F: "Rapid detection of SARS-CoV-2 antibodies using electrochemical impedance-based detector", BIOSENSORS AND BIOELECTRONICS, ELSEVIER SCIENCE LTD, UK, AMSTERDAM , NL, vol. 171, 7 October 2020 (2020-10-07), Amsterdam , NL , XP086320212, ISSN: 0956-5663, DOI: 10.1016/j.bios.2020.112709
HANSON QUINLIN M., WILSON KELLI M., SHEN MIN, ITKIN ZINA, EASTMAN RICHARD T., SHINN PAUL, HALL MATTHEW D.: "Targeting ACE2–RBD Interaction as a Platform for COVID-19 Therapeutics: Development and Drug-Repurposing Screen of an AlphaLISA Proximity Assay", ACS PHARMACOLOGY & TRANSLATIONAL SCIENCE, vol. 3, no. 6, 11 December 2020 (2020-12-11), pages 1352 - 1360, XP055868242, ISSN: 2575-9108, DOI: 10.1021/acsptsci.0c00161
LIU YINGXIA, HUANG FENGMING, XU JUN, YANG PENGHUI, QIN YUHAO, CAO MENGLI, WANG ZHAOQIN, LI XIAOHE, ZHANG SHAOGENG, YE LU, LV JINGJ: "Anti-hypertensive Angiotensin II receptor blockers associated to mitigation of disease severity in elderly COVID-19 patients", MEDRXIV, 27 March 2020 (2020-03-27), XP055923141, Retrieved from the Internet
Attorney, Agent or Firm:
LUNG TIN INTELLECTUAL PROPERTY AGENT LTD. (CN)
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