Title:
CANCER ORIGIN CELLS DEFINED BY GENES, AND CLASSIFICATION METHOD THEREFOR
Document Type and Number:
WIPO Patent Application WO/2023/195812
Kind Code:
A1
Abstract:
The present invention relates to a method for isolating brain cancer origin cells, the method comprising a step of determining the expression level of at least one protein selected from a group consisting of ADCY2, ADGRV1, AQP4, ATP1A2, EGFR, KALRN, MT2A, NRCAM, NRXN1, PTPRZ1, RBMS3, RORA, SLC1A2, SORBS1, VIM, CERCAM, MBP, PLP1, PLXDC2, TF, TMEM144, and XKR4, or a gene coding therefor, in cells separated from the subventricular zone. The inventors have found that in brain cancer, particularly in glioblastoma, for which effective treatments are difficult to discover and which is very poor in prognosis and survival rate, the factors not only function as reliable diagnostic markers, but also, through the expression regulation thereof, can be used beneficially as a fundamental therapeutic composition that suppresses the tumor and significantly improves the survival rate of patients with glioblastoma, a refractory disease.
Inventors:
KANG SEOK-GU (KR)
CHOI RANJOO (KR)
YOON SEONJIN (KR)
CHOI RANJOO (KR)
YOON SEONJIN (KR)
Application Number:
PCT/KR2023/004699
Publication Date:
October 12, 2023
Filing Date:
April 07, 2023
Export Citation:
Assignee:
UNIV YONSEI IACF (KR)
International Classes:
C12Q1/6886; C12N5/09; G01N33/574
Foreign References:
| US20210222253A1 | 2021-07-22 | |||
| KR20180024262A | 2018-03-08 | |||
| KR20190095074A | 2019-08-14 | |||
| US20170051360A1 | 2017-02-23 | |||
| KR20120038339A | 2012-04-23 |
Attorney, Agent or Firm:
PADO IP LAW PLLC (KR)
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