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Title:
CEREBRAL VASOSPASM INHIBITOR
Document Type and Number:
WIPO Patent Application WO/2007/135992
Kind Code:
A1
Abstract:
Disclosed is an inhibitor of cerebral vasospasm, which is effective on cerebral vasospasm occurring after subarachnoid hemorrhage and has few adverse side-effects. The inhibitor comprises an anti-HMGB1 monoclonal antibody as an active ingredient.

Inventors:
NISHIBORI MASAHIRO (JP)
MORI SHUJI (JP)
TAKAHASHI HIDEO (JP)
TOMONO YASUKO (JP)
DATE ISAO (JP)
ONO SHIGEKI (JP)
Application Number:
PCT/JP2007/060231
Publication Date:
November 29, 2007
Filing Date:
May 18, 2007
Export Citation:
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Assignee:
UNIV OKAYAMA NAT UNIV CORP (JP)
NISHIBORI MASAHIRO (JP)
MORI SHUJI (JP)
TAKAHASHI HIDEO (JP)
TOMONO YASUKO (JP)
DATE ISAO (JP)
ONO SHIGEKI (JP)
International Classes:
A61K39/395; A61P9/00
Foreign References:
JP2003520763A2003-07-08
JP2005537253A2005-12-08
JP3882090B12007-02-14
JP2003520763A2003-07-08
JP2005537253A2005-12-08
Other References:
DATE I. ET AL.: "Kumomakka Shukketsu Go no No Kekkan Renshuku ni Taisuru Idenshi Chiryo", NO TO JUNKAN, MEDICAL VIEW CO., LTD., vol. 7, no. 1, 2002, pages 47 - 51, XP003019245
MARUYAMA I.: "Seitai Shinshu to HMGB1: Okurete Yattekkita Seitai Chishi Inshi", SURGICAL TRAUMA & IMMUNOLOGICAL RESPONSES, MEDICAL VIEW CO., LTD., vol. 15, no. 1, 31 March 2006 (2006-03-31), pages 31 - 36, XP003019246
Attorney, Agent or Firm:
UEKI, Kyuichi et al. (1-16 Dojima 2-chome, Kita-ku, Osaka-sh, Osaka 03, JP)
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