Title:
COMPOSITION AND METHOD FOR SUPPRESSING INCREASE IN BLOOD GLUCOSE LEVEL
Document Type and Number:
WIPO Patent Application WO/2020/031952
Kind Code:
A1
Abstract:
The purpose of the present invention is to provide a composition for suppressing an increase in blood glucose level which comprises a heat stable substance as an active ingredient, a composition for suppressing an increase in blood glucose level which can be taken at any timing, i.e., not limited to before or during a meal and suppress an increase in postprandial blood glucose level, and a method for suppressing an increase in blood glucose level.
The present invention pertains to a composition for suppressing an increase in blood glucose level, etc., said composition comprising isoxanthohumol as an active ingredient.
Inventors:
FUKIZAWA SHINYA (JP)
NONAKA YUJI (JP)
YAMASHITA MAI (JP)
NONAKA YUJI (JP)
YAMASHITA MAI (JP)
Application Number:
PCT/JP2019/030711
Publication Date:
February 13, 2020
Filing Date:
August 05, 2019
Export Citation:
Assignee:
SUNTORY HOLDINGS LTD (JP)
International Classes:
A23L33/105; A23L2/52; A61K31/12; A61P3/10
Foreign References:
| US20070218155A1 | 2007-09-20 | |||
| JP2010513360A | 2010-04-30 | |||
| JP2001252064A | 2001-09-18 | |||
| JP2006306800A | 2006-11-09 | |||
| JP2009518429A | 2009-05-07 |
Other References:
RAMIREZ, AG ET AL.: "Highly isoxanthohumol enriched hop extract obtained by pressurized hot water extraction (PHWE", CHEMICAL AND FUNCTIONAL CHARACTERIZATION INNOVATIVE FOOD SCIENCE AND EMERGING TECHNOLOGIES, vol. 16, October 2012 (2012-10-01), pages 54 - 60, XP055683579, ISSN: 1466-8564
NEGRAO, R ET AL.: "Isoxanthohumol modulates angiogenesis and inflammation via vascular endothelial growth factor receptor, tumor necrosis factor alpha and nuclear factor kappa B pathways", BIOFACTORS, vol. 39, no. 6, November 2013 (2013-11-01), pages 608 - 622, XP055683580, ISSN: 1872-8081
ANDO, Y ET AL.: "Tumor Necrosis Factor (TNF) - a -induced Repression of GKAP42 Protein Levels through cGMP-dependent Kinase (cGK)-Ialpha Causes Insulin Resistance in 3T3-L1 Adipocytes", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 290, no. 9, 27 February 2015 (2015-02-27), pages 5881 - 5892, XP055683583, ISSN: 1083-351X
YANG, JY ET AL.: "Effect of xanthohumol and isoxanthohumol on 3T3-L1 cell apoptosis and adipogenesis", APOPTOSIS, vol. 12, 2007, pages 1953 - 1963, XP019523444, ISSN: 1573-675X, DOI: 10.1007/s10495-007-0130-4
LANCET, vol. 354, 1999, pages 617 - 621
ARCH BIOCHEM BIOPHYS, vol. 599, 2016, pages 22 - 30
J NUTR BIOCHEM, vol. 45, 2017, pages 39 - 47
FREE RADICAL BIO MED, vol. 89, 2015, pages 486 - 497
See also references of EP 3834629A4
NEGRAO, R ET AL.: "Isoxanthohumol modulates angiogenesis and inflammation via vascular endothelial growth factor receptor, tumor necrosis factor alpha and nuclear factor kappa B pathways", BIOFACTORS, vol. 39, no. 6, November 2013 (2013-11-01), pages 608 - 622, XP055683580, ISSN: 1872-8081
ANDO, Y ET AL.: "Tumor Necrosis Factor (TNF) - a -induced Repression of GKAP42 Protein Levels through cGMP-dependent Kinase (cGK)-Ialpha Causes Insulin Resistance in 3T3-L1 Adipocytes", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 290, no. 9, 27 February 2015 (2015-02-27), pages 5881 - 5892, XP055683583, ISSN: 1083-351X
YANG, JY ET AL.: "Effect of xanthohumol and isoxanthohumol on 3T3-L1 cell apoptosis and adipogenesis", APOPTOSIS, vol. 12, 2007, pages 1953 - 1963, XP019523444, ISSN: 1573-675X, DOI: 10.1007/s10495-007-0130-4
LANCET, vol. 354, 1999, pages 617 - 621
ARCH BIOCHEM BIOPHYS, vol. 599, 2016, pages 22 - 30
J NUTR BIOCHEM, vol. 45, 2017, pages 39 - 47
FREE RADICAL BIO MED, vol. 89, 2015, pages 486 - 497
See also references of EP 3834629A4
Attorney, Agent or Firm:
YASUTOMI & ASSOCIATES (JP)
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