COMPOSITIONS AND METHODS FOR THE DIAGNOSIS AND TREATMENT OF DISORDERS INVOLVING ANGIOGENESIS

Title:

COMPOSITIONS AND METHODS FOR THE DIAGNOSIS AND TREATMENT OF DISORDERS INVOLVING ANGIOGENESIS

Document Type and Number:

WIPO Patent Application WO2002000690

Kind Code:

A3

Abstract:

Compositions and methods are disclosed for stimulating or inhibiting angiogenesis and/or cardiovascularization in mammals, including humans. Pharmaceutical compositions are based on polypeptides or antagonists thereto that have been identified for one or more of these uses. Disorders that can be diagnosed, prevented, or treated by the compositions herein include trauma such as wounds, various cancers, and disorders of the vessels including atherosclerosis and cardiac hypertrophy.In addition, the present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

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Inventors:

BAKER KEVIN P (US)
FERRARA NAPOLEONE (US)
GERBER HANSPETER (US)
GERRITSEN MARY E (US)
GODDARD AUDREY (US)
GODOWSKI PAUL J (US)
GURNEY AUSTIN L (US)
HILLAN KENNETH J (US)
MARSTERS SCOT A (US)
PAN JAMES (US)
PAONI NICHOLAS F (US)
STEPHAN JEAN-PHILIPPE F (US)
WATANABE COLIN K (US)
WILLIAMS P MICKEY (US)
WOOD WILLIAM I (US)
YE WEILAN (US)

Application Number:

PCT/US2001/019692

Publication Date:

March 13, 2003

Filing Date:

June 20, 2001

Export Citation:

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Assignee:

GENENTECH INC (US)
BAKER KEVIN P (US)
FERRARA NAPOLEONE (US)
GERBER HANSPETER (US)
GERRITSEN MARY E (US)
GODDARD AUDREY (US)
GODOWSKI PAUL J (US)
GURNEY AUSTIN L (US)
HILLAN KENNETH J (US)
MARSTERS SCOT A (US)
PAN JAMES (US)
PAONI NICHOLAS F (US)
STEPHAN JEAN-PHILIPPE F (US)
WATANABE COLIN K (US)
WILLIAMS P MICKEY (US)
WOOD WILLIAM I (US)
YE WEILAN (US)

International Classes:

C12N15/09; A61K38/17; A61K38/22; A61K39/395; A61K48/00; A61P9/00; A61P9/04; A61P9/10; A61P27/02; A61P35/00; A61P43/00; C07K14/00; C07K14/47; C07K16/18; C07K16/46; C07K19/00; C12N1/19; C12N1/21; C12N5/07; C12N5/071; C12N5/10; C12N15/12; C12P21/02; C12P21/08; (IPC1-7): C07K14/47; C12N15/12; A61K38/17; C07K16/18

Domestic Patent References:

WO1999046281A2	1999-09-16
WO1999050405A1	1999-10-07
WO1999043802A2	1999-09-02
WO1999010363A1	1999-03-04
WO1999033979A2	1999-07-08
WO1995029242A1	1995-11-02
WO2000053756A2	2000-09-14
WO2000053751A1	2000-09-14
WO2001000828A2	2001-01-04
WO2002008284A2	2002-01-31

Foreign References:

US5968744A	1999-10-19
EP0335243A2	1989-10-04

Other References:

FOLKMAN J: "CLINICAL APPLICATIONS OF RESEARCH ON ANGIOGENESIS", NEW ENGLAND JOURNAL OF MEDICINE, THE, MASSACHUSETTS MEDICAL SOCIETY, WALTHAM, MA, US, vol. 333, no. 26, 28 December 1995 (1995-12-28), pages 1757 - 1763, XP000654557, ISSN: 0028-4793
KLAGSBRUN M: "REGULATORS OF ANGIOGENESIS: STIMULATORS, INHIBITORS, AND EXTRACELLULAR MATRIX", JOURNAL OF CELLULAR BIOCHEMISTRY, LISS, NEW YORK, NY, US, vol. 47, no. 3, 1 November 1991 (1991-11-01), pages 199 - 200, XP000616588, ISSN: 0730-2312

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