Title:
COMPOSITIONS AND METHODS FOR TARGETED EPIGENETIC MODIFICATION
Document Type and Number:
WIPO Patent Application WO/2015/138870
Kind Code:
A3
Abstract:
The present disclosure is directed to compositions and methods for targeting and modulating the epigenetic "state" (e.g., methylation state) of one or more genes. For example, the present disclosure is directed, in part, to transcription activator-like effector (TALE) fusion protein compositions and methods of their use in targeting and modulating the epigenetic state of one or more genes.
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Inventors:
KAESTNER KLAUS H (US)
Application Number:
PCT/US2015/020405
Publication Date:
October 29, 2015
Filing Date:
March 13, 2015
Export Citation:
Assignee:
UNIV PENNSYLVANIA (US)
International Classes:
C07H21/04; C12N5/00; C12N9/00; C12P21/04
Domestic Patent References:
| WO2013143597A1 | 2013-10-03 |
Other References:
MOSS.: "Creating new beta cells: cellular transmutation by genomic alchemy", J CLIN INVEST., vol. 123, no. 3, March 2013 (2013-03-01), pages 1007 - 1010, XP055233673
BRAMSWIG ET AL.: "Epigenomic plasticity enables human pancreatic alpha to beta cell reprogramming.", J CLIN INVEST, vol. 123, no. 3, March 2013 (2013-03-01), pages 1275 - 1284, XP055233675
MENDENHALL ET AL.: "Locus-specific editing of histone modifications at endogenous enhancers using programmable TALE-LSD1 fusions.", NATURE BIOTECHNOL, vol. 31, no. 12, December 2013 (2013-12-01), pages 1133 - 1137, XP055233676
BRAMSWIG ET AL.: "Epigenomic plasticity enables human pancreatic alpha to beta cell reprogramming.", J CLIN INVEST, vol. 123, no. 3, March 2013 (2013-03-01), pages 1275 - 1284, XP055233675
MENDENHALL ET AL.: "Locus-specific editing of histone modifications at endogenous enhancers using programmable TALE-LSD1 fusions.", NATURE BIOTECHNOL, vol. 31, no. 12, December 2013 (2013-12-01), pages 1133 - 1137, XP055233676
Attorney, Agent or Firm:
RAGUSA, Paul, A. et al. (30 Rockefeller PlazaNew York, NY, US)
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