Title:
オリゴヌクレオチドの製造方法
Document Type and Number:
Japanese Patent JP6950529
Kind Code:
B2
Abstract:
The invention provides a novel method for producing an oligonucleotide using a nucleoside or oligonucleotide that is easy to isolate and has high storage stability. The oligonucleotide production method includes a step of subjecting a nucleoside or oligonucleotide having a pseudo solid phase-protecting group in at least one location selected from the group consisting of 2'-position, 3'-position, 5'-position and a nucleobase moiety and having a 5'-hydroxyl group or a 3'-hydroxyl group, to H-phosphonation to convert the 5'-hydroxyl group or the 3'-hydroxyl group into an H-phosphonated form.
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Inventors:
Sugawara Yudai
Application Number:
JP2017551927A
Publication Date:
October 13, 2021
Filing Date:
November 17, 2016
Export Citation:
Assignee:
Nissan Chemical Co., Ltd.
International Classes:
C07H21/04
Domestic Patent References:
| JP2010275254A | ||||
| JP60174797A |
Foreign References:
| WO2014077292A1 | ||||
| WO2012157723A1 | ||||
| WO2013122236A1 | ||||
| WO2005028494A1 |
Other References:
GOPALAKRISHNAN, B. et al.,A Virtual Screening Approach for Thymidine Monophosphate Kinase Inhibitors as Antitubercular Agents,Journal of Chemical Information and Modeling,2005年,Vol.45, No.4,pp.1101-1108, Supporting Information,ISSN 1549-9596
BAKER, B. R. et al.,Irreversible enzyme inhibitors. 195. Inhibitors of thymidine kinase from Walker 256 carcinoma derive,Journal of Medicinal Chemistry,1972年,Vol.15, No.9,pp.940-944,ISSN 0022-2623
BAKER, B. R. et al.,Irreversible enzyme inhibitors. 195. Inhibitors of thymidine kinase from Walker 256 carcinoma derive,Journal of Medicinal Chemistry,1972年,Vol.15, No.9,pp.940-944,ISSN 0022-2623
Attorney, Agent or Firm:
Patent business corporation Tsukuni