Title:
DESLEUCYL GLYCOPEPTIDE ANTIBIOTICS AND METHODS OF MAKING SAME
Document Type and Number:
WIPO Patent Application WO2000059528
Kind Code:
A8
Abstract:
Compounds that are analogs of glycopeptide antibiotics are disclosed. The compounds have the formula A1-A2-A3-A4-A5-A6-A7 wherein each of the groups A2 to A7 is a modified or unmodified alpha -amino acid residue, A1 is optional and, when present, is an organic group other than N-substituted leucine, and at least one of the groups A1 to A7 is linked via a glycosidic bond to one or more glycosidic groups each having one or more sugar residues, wherein at least one of said sugar residues is modified to bear at least one hydrophobic substituent. Methods of making these compounds, compositions including these compounds, and methods of using the compounds to treat infections in a host are also disclosed.
Inventors:
KAHNE DANIEL
WALKER SUZANNE
SILVA DOMINGOS J
WALKER SUZANNE
SILVA DOMINGOS J
Application Number:
PCT/US2000/008559
Publication Date:
June 21, 2001
Filing Date:
March 31, 2000
Export Citation:
Assignee:
UNIV PRINCETON (US)
INCARA PHARMACEUTICALS INC (US)
INCARA PHARMACEUTICALS INC (US)
International Classes:
C07K9/00; A61K38/00; (IPC1-7): A61K38/08; A61K38/14; C07K1/107; C07K7/06; C07K9/00
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