Title:
USE OF ErbB RECEPTOR LIGANDS IN TREATING DIABETES
Document Type and Number:
WIPO Patent Application WO2000059525
Kind Code:
A3
Abstract:
The invention provides methods for treating pancreatic dysfunction, particularly diabetes, in mammals using ErbB receptor ligands, such as heregulin, betacellulin, and EGF. Methods of treating such conditions using anti-ErbB receptor agonist antibodies are further provided. The methods of the invention may be performed by direct administration of such therapeutically useful agents to mammals, or alternatively, by exposing certain pancreatic cell types to such agents in vitro and subsequently transplanting the treated cells to a mammal.
Inventors:
HUANG XIAOJIAN
STEWART TIMOTHY ANDREW
STEWART TIMOTHY ANDREW
Application Number:
PCT/US2000/009240
Publication Date:
February 08, 2001
Filing Date:
April 05, 2000
Export Citation:
Assignee:
GENENTECH INC (US)
International Classes:
A61K31/7088; A61K35/39; A61K35/76; A61K38/00; A61K38/18; A61K39/395; A61K45/00; A61K48/00; A61P3/10; A61P9/00; A61P9/02; A61P9/10; A61P9/14; A61P13/12; A61P43/00; C07K16/32; C12N5/07; C12N5/071; C12N5/074; A61K39/00; (IPC1-7): A61K38/18; A61K39/395; A61P3/10
Domestic Patent References:
| WO1997017086A2 | 1997-05-15 | |||
| WO1995019785A1 | 1995-07-27 | |||
| WO1996030403A1 | 1996-10-03 |
Other References:
GONUL B ET AL: "Effect of EGF on the corneal wound healing of alloxan diabetic mice.", EXPERIMENTAL EYE RESEARCH, (1992 APR) 54 (4) 519-24., XP000917539
HUOTARI M A ET AL: "Growth factor-mediated proliferation and differentiation of insulin -producing INS-1 and RINm5F cells: identification of betacellulin as a novel beta - cell mitogen.", ENDOCRINOLOGY, (1998 APR) 139 (4) 1494-9., XP000917303
DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; MIETTINEN, P. J. (1) ET AL: "Proliferation and migration of pancreatic beta -cells is disturbed after inactivation of the EGF -R function.", XP002144679, retrieved from STN
HUOTARI M A ET AL: "Growth factor-mediated proliferation and differentiation of insulin -producing INS-1 and RINm5F cells: identification of betacellulin as a novel beta - cell mitogen.", ENDOCRINOLOGY, (1998 APR) 139 (4) 1494-9., XP000917303
DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; MIETTINEN, P. J. (1) ET AL: "Proliferation and migration of pancreatic beta -cells is disturbed after inactivation of the EGF -R function.", XP002144679, retrieved from STN
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