Title:
DIAGNOSIS AND TREATMENT OF DISEASES USING ANTI-ANTI-T-CELL RECEPTOR VBETA ANTI-BODIES OR PEPTIDES WHICH ARE RECOGNIZED BY SAID ANTIBODIES, AND ENDOCRINE SECRETION REGULATORY PROTEIN I (ESRP1)
Document Type and Number:
WIPO Patent Application WO1999005175
Kind Code:
A3
Abstract:
The invention provides monoclonal and polyclonal antibodies recognising molecules on secretory cells of various tissue targets of autoimmune disease allowing a unifying method of preventing and treating autoimmune diseases and other conditions where hormonal dysregulation, hyperinsulinaemia and insulin resistance are involved. It also provides a method for detecting similar antibodies in human sera or other body fluids which can be used in the development of diagnostic kits. Treatment methods arising from this invention comprise the administration of preparations of the antibodies, their target molecules and vectors containing coding sequences of the antibodies and their target molecules.
Inventors:
MATOSSIAN-ROGERS ARPI (GB)
Application Number:
PCT/GB1998/002151
Publication Date:
June 10, 1999
Filing Date:
July 20, 1998
Export Citation:
Assignee:
MATOSSIAN ROGERS ARPI (GB)
International Classes:
A61K38/00; A61K38/16; A61K38/17; A61K39/395; A61P3/10; C12N15/09; A61P9/00; A61P35/00; A61P37/06; A61P43/00; C07K14/435; C07K14/47; C07K16/00; C07K16/42; C12P21/02; C12P21/08; G01N33/564; G01N33/68; (IPC1-7): C12N15/09; A61K39/395; A61K38/16; C07K16/42; C07K14/435
Domestic Patent References:
| WO1992012996A2 | 1992-08-06 | |||
| WO1991009623A1 | 1991-07-11 |
Foreign References:
| US5665355A | 1997-09-09 |
Other References:
ACHA-ORBEA, HANS: "Anti - T - cell receptor V. beta. antibodies in autoimmunity", IMMUNOL. SER. (1993), 59(MONOCLONAL ANTIBODIES AND PEPTIDE THERAPY IN AUTOIMMUNE DISEASES), 193-202 CODEN: IMSED7;ISSN: 0092-6019, XP002086407
DAVID C S ET AL: "A SIGNIFICANT REDUCTION IN THE INCIDENCE OF COLLAGEN INDUCED ARTHRITIS IN MICE TREATED WITH ANTI - TCR V - BETA ANTIBODIES.", MEETING ON MOLECULAR BIOLOGY AND THE IMMUNOPATHOGENESIS OF RHEUMATOID ARTHRITIS HELD AT THE 20TH ANNUAL MEETING OF THE KEYSTONE SYMPOSIA ON MOLECULAR AND CELLULAR BIOLOGY, LAKE TAHOE, CALIFORNIA, USA, MARCH 15-21, 1991. J CELL BIOCHEM SUPP 15; PART E, pages 179, Abtract No. 0404,, XP002086408
CELLI, C. M. ET AL: "Origin and pathogenesis of antiphospholipid antibodies", BRAZ. J. MED. BIOL. RES. (1998), 31(6), 723-732 CODEN: BJMRDK;ISSN: 0100-879X, XP002086409
DAVID C S ET AL: "A SIGNIFICANT REDUCTION IN THE INCIDENCE OF COLLAGEN INDUCED ARTHRITIS IN MICE TREATED WITH ANTI - TCR V - BETA ANTIBODIES.", MEETING ON MOLECULAR BIOLOGY AND THE IMMUNOPATHOGENESIS OF RHEUMATOID ARTHRITIS HELD AT THE 20TH ANNUAL MEETING OF THE KEYSTONE SYMPOSIA ON MOLECULAR AND CELLULAR BIOLOGY, LAKE TAHOE, CALIFORNIA, USA, MARCH 15-21, 1991. J CELL BIOCHEM SUPP 15; PART E, pages 179, Abtract No. 0404,, XP002086408
CELLI, C. M. ET AL: "Origin and pathogenesis of antiphospholipid antibodies", BRAZ. J. MED. BIOL. RES. (1998), 31(6), 723-732 CODEN: BJMRDK;ISSN: 0100-879X, XP002086409
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