Title:
EPO KNOCKOUT GFP ANEMIC MOUSE
Document Type and Number:
WIPO Patent Application WO/2012/137449
Kind Code:
A1
Abstract:
The present invention pertains to a model animal characterized by being spontaneously anemic. More specifically, the present invention pertains to: a transgenic non-human mammal characterized by spontaneous anemia accompanying a post-natal decrease in production of erythropoietin (Epo); Epo-producing cells prepared from the transgenic non-human mammal; and a method for screening the Epo-producing cells.
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Inventors:
YAMAMOTO MASAYUKI (JP)
MINEGISHI NAOKO (JP)
YAMAZAKI SHUN (JP)
MINEGISHI NAOKO (JP)
YAMAZAKI SHUN (JP)
Application Number:
PCT/JP2012/002207
Publication Date:
October 11, 2012
Filing Date:
March 29, 2012
Export Citation:
Assignee:
TOHOKU TECHNO ARCH CO LTD (JP)
YAMAMOTO MASAYUKI (JP)
MINEGISHI NAOKO (JP)
YAMAZAKI SHUN (JP)
YAMAMOTO MASAYUKI (JP)
MINEGISHI NAOKO (JP)
YAMAZAKI SHUN (JP)
International Classes:
A01K67/027; C12N5/10; C12N15/09; C12Q1/02
Foreign References:
| JP2011083664A | 2011-04-28 |
Other References:
ZEIGLER B.M. ET AL.: "A mouse model for an erythropoietin-deficiency anemia", DIS.MODEL. MECH., vol. 3, no. 11-12, 2010, pages 763 - 72, XP055125433
MAXWELL P.H. ET AL.: "Identification of the renal erythropoietin-producing cells using transgenic mice", KIDNEY INT., vol. 44, no. 5, 1993, pages 1149 - 1162, XP055125436
SHUN YAMAZAKI ET AL.: "Epo Idenshi Kesshitsu Mouse no Rescuer to Joken Tsuki Epo Idenshi Hakai Mouse no Juritsu", JOURNAL OF JAPANESE BIOCHEMICAL SOCIETY, 2009, pages ROMBUNNO.4T4P-11, XP008170936
SHUN YAMAZAKI ET AL.: "Seiju ni Okeru Yudoteki Erythropoietin Idenshi Hakai no Zoketsu ni Ataeru Eikyo", JOURNAL OF JAPANESE BIOCHEMICAL SOCIETY, 2010, pages ROMBUNNO.1P-0304, XP008170918
OBARA N. ET AL.: "Repression via the GATA box is essential for tissue-specific erythropoietin gene expression", BLOOD, vol. 111, no. 10, 2008, pages 5223 - 32, XP055125443
PAN X. ET AL.: "Isolation and characterization of renal erythropoietin-producing cells from genetically produced anemia mice", PLOS ONE, vol. 6, no. 10, October 2011 (2011-10-01), pages E25839, XP055125437
TAKEDA A; TADA T; SHINOHARA S; MOGI Y; MATSUI N: "Factors contributing to higher hematocrit levels in hemodialysis patients not receiving recombinant human erythropoietin", AMERICAN JOURNAL OF KIDNEY DISEASES: THE OFFICIAL JOURNAL OF THE NATIONAL KIDNEY FOUNDATION, vol. 40, 2002, pages 104 - 109, XP028836450, DOI: doi:10.1053/ajkd.2002.33918
GAGNON RF; DUGUID WP: "A reproducible model for chronic renal failure in the mouse", UROLOGICAL RESEARCH, vol. 11, 1983, pages 11 - 14
GAGNON RF; GALLIMORE B: "Characterization of a mouse model of chronic uremia", UROLOGICAL RESEARCH, vol. 16, 1988, pages 119 - 126
GARCIA DL; ANDERSON S; RENNKE HG; BRENNER BM: "Anemia lessens and its prevention with recombinant human erythropoietin worsens glomerular injury and hypertension in rats with reduced renal mass", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 85, 1988, pages 6142 - 6146
WU H; LIU X; JAENISCH R; LODISH HF: "Generation of committed erythroid BFU-E and CFU-E progenitors does not require erythropoietin or the erythropoietin receptor", CELL, vol. 83, 1995, pages 59 - 67
SHUN YAMAZAKI; NORIO SUZUKI; NAOSHI OBARA; XIAOQING PAN; IKUO HIRANO; KOU-ICHI JISHAGE; KURISU HONDA; NAOKO MINEGISHI; MASAYUKI YA: "Rescue of Erythropoietin-Deficient Mice From Anemia by Complementation with BAC Transgene", BLOOD (ASH ANNUAL MEETING ABSTRACTS, vol. 114, November 2009 (2009-11-01), pages 3614, XP008173018
ZEIGLER BM; VAJDOS J; QIN W; LOVERRO L; NISS K: "A mouse model for an erythropoietin- deficiency anemia", DISEASE MODELS & MECHANISMS
KAPITSINOU PP; LIU Q; UNGER TL ET AL.: "Hepatic HIF-2 regulates erythropoietic responses to hypoxia in renal anemia", BLOOD, vol. 116, 2010, pages 3039 - 3048
MAXWELL PH; OSMOND MK; PUGH CW ET AL.: "Identification of the renal erythropoietin- producing cells using transgenic mice", KIDNEY INT., vol. 44, 1993, pages 1149 - 1162, XP055125436, DOI: doi:10.1038/ki.1993.362
EL HASNAOUI-SAADANI R; PICHON A; MARCHANT D ET AL.: "Cerebral adaptations to chronic anemia in a model of erythropoietin-deficient mice exposed to hypoxia", AMERICAN JOURNAL OF PHYSIOLOGY - REGULATORY INTEGRATIVE & COMPARATIVE PHYSIOLOGY, vol. 296, 2009, pages R801 - 811
RINSCH C; DUPRAZ P; SCHNEIDER BL ET AL.: "Delivery of erythropoietin by encapsulated myoblasts in a genetic model of severe anemia", KIDNEY INT., vol. 62, 2002, pages 1395 - 1401, XP055148883, DOI: doi:10.1046/j.1523-1755.2002.00574.x
BINLEY K; ASKHAM Z; IQBALL S ET AL.: "Long-term reversal of chronic anemia using a hypoxia-regulated erythropoietin gene therapy", BLOOD, vol. 100, 2002, pages 2406 - 2413, XP002241588, DOI: doi:10.1182/blood-2002-02-0605
GRUBER M; HU C-J; JOHNSON RS; BROWN EJ; KEITH B; SIMON MC: "Acute postnatal ablation of Hif-2{alpha} results in anemia", PNAS, vol. 104, 2007, pages 2301 - 2306, XP055149291, DOI: doi:10.1073/pnas.0608382104
SUZUKI N; OBARA N; YAMAMOTO M; HELMUT S; BERNHARD BN: "Methods in Enzymology", vol. 435, 2007, ACADEMIC PRESS, article "Use of Gene[hyphen (true graphic)]Manipulated Mice in the Study of Erythropoietin Gene Expression", pages: 157 - 177
OBARA N; SUZUKI N; KIM K; NAGASAWA T; IMAGAWA S; YAMAMOTO M: "Repression via the GATA box is essential for tissue-specific erythropoietin gene expression", BLOOD, vol. 111, 2008, pages 5223 - 5232, XP055125443, DOI: doi:10.1182/blood-2007-10-115857
MORITA M. ET AL., EMBO J., vol. 22, no. 5, 2003, pages 1134 - 1146
TAKAHASHI S. ET AL., M. J. BIOL. CHEM., vol. 272, no. 19, 1997, pages 12611 - 12615
IMAGAWA S ET AL., INT. J. HEMATOL., vol. 75, no. 4, 2002, pages 376 - 381
See also references of EP 2695515A4
MAXWELL P.H. ET AL.: "Identification of the renal erythropoietin-producing cells using transgenic mice", KIDNEY INT., vol. 44, no. 5, 1993, pages 1149 - 1162, XP055125436
SHUN YAMAZAKI ET AL.: "Epo Idenshi Kesshitsu Mouse no Rescuer to Joken Tsuki Epo Idenshi Hakai Mouse no Juritsu", JOURNAL OF JAPANESE BIOCHEMICAL SOCIETY, 2009, pages ROMBUNNO.4T4P-11, XP008170936
SHUN YAMAZAKI ET AL.: "Seiju ni Okeru Yudoteki Erythropoietin Idenshi Hakai no Zoketsu ni Ataeru Eikyo", JOURNAL OF JAPANESE BIOCHEMICAL SOCIETY, 2010, pages ROMBUNNO.1P-0304, XP008170918
OBARA N. ET AL.: "Repression via the GATA box is essential for tissue-specific erythropoietin gene expression", BLOOD, vol. 111, no. 10, 2008, pages 5223 - 32, XP055125443
PAN X. ET AL.: "Isolation and characterization of renal erythropoietin-producing cells from genetically produced anemia mice", PLOS ONE, vol. 6, no. 10, October 2011 (2011-10-01), pages E25839, XP055125437
TAKEDA A; TADA T; SHINOHARA S; MOGI Y; MATSUI N: "Factors contributing to higher hematocrit levels in hemodialysis patients not receiving recombinant human erythropoietin", AMERICAN JOURNAL OF KIDNEY DISEASES: THE OFFICIAL JOURNAL OF THE NATIONAL KIDNEY FOUNDATION, vol. 40, 2002, pages 104 - 109, XP028836450, DOI: doi:10.1053/ajkd.2002.33918
GAGNON RF; DUGUID WP: "A reproducible model for chronic renal failure in the mouse", UROLOGICAL RESEARCH, vol. 11, 1983, pages 11 - 14
GAGNON RF; GALLIMORE B: "Characterization of a mouse model of chronic uremia", UROLOGICAL RESEARCH, vol. 16, 1988, pages 119 - 126
GARCIA DL; ANDERSON S; RENNKE HG; BRENNER BM: "Anemia lessens and its prevention with recombinant human erythropoietin worsens glomerular injury and hypertension in rats with reduced renal mass", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 85, 1988, pages 6142 - 6146
WU H; LIU X; JAENISCH R; LODISH HF: "Generation of committed erythroid BFU-E and CFU-E progenitors does not require erythropoietin or the erythropoietin receptor", CELL, vol. 83, 1995, pages 59 - 67
SHUN YAMAZAKI; NORIO SUZUKI; NAOSHI OBARA; XIAOQING PAN; IKUO HIRANO; KOU-ICHI JISHAGE; KURISU HONDA; NAOKO MINEGISHI; MASAYUKI YA: "Rescue of Erythropoietin-Deficient Mice From Anemia by Complementation with BAC Transgene", BLOOD (ASH ANNUAL MEETING ABSTRACTS, vol. 114, November 2009 (2009-11-01), pages 3614, XP008173018
ZEIGLER BM; VAJDOS J; QIN W; LOVERRO L; NISS K: "A mouse model for an erythropoietin- deficiency anemia", DISEASE MODELS & MECHANISMS
KAPITSINOU PP; LIU Q; UNGER TL ET AL.: "Hepatic HIF-2 regulates erythropoietic responses to hypoxia in renal anemia", BLOOD, vol. 116, 2010, pages 3039 - 3048
MAXWELL PH; OSMOND MK; PUGH CW ET AL.: "Identification of the renal erythropoietin- producing cells using transgenic mice", KIDNEY INT., vol. 44, 1993, pages 1149 - 1162, XP055125436, DOI: doi:10.1038/ki.1993.362
EL HASNAOUI-SAADANI R; PICHON A; MARCHANT D ET AL.: "Cerebral adaptations to chronic anemia in a model of erythropoietin-deficient mice exposed to hypoxia", AMERICAN JOURNAL OF PHYSIOLOGY - REGULATORY INTEGRATIVE & COMPARATIVE PHYSIOLOGY, vol. 296, 2009, pages R801 - 811
RINSCH C; DUPRAZ P; SCHNEIDER BL ET AL.: "Delivery of erythropoietin by encapsulated myoblasts in a genetic model of severe anemia", KIDNEY INT., vol. 62, 2002, pages 1395 - 1401, XP055148883, DOI: doi:10.1046/j.1523-1755.2002.00574.x
BINLEY K; ASKHAM Z; IQBALL S ET AL.: "Long-term reversal of chronic anemia using a hypoxia-regulated erythropoietin gene therapy", BLOOD, vol. 100, 2002, pages 2406 - 2413, XP002241588, DOI: doi:10.1182/blood-2002-02-0605
GRUBER M; HU C-J; JOHNSON RS; BROWN EJ; KEITH B; SIMON MC: "Acute postnatal ablation of Hif-2{alpha} results in anemia", PNAS, vol. 104, 2007, pages 2301 - 2306, XP055149291, DOI: doi:10.1073/pnas.0608382104
SUZUKI N; OBARA N; YAMAMOTO M; HELMUT S; BERNHARD BN: "Methods in Enzymology", vol. 435, 2007, ACADEMIC PRESS, article "Use of Gene[hyphen (true graphic)]Manipulated Mice in the Study of Erythropoietin Gene Expression", pages: 157 - 177
OBARA N; SUZUKI N; KIM K; NAGASAWA T; IMAGAWA S; YAMAMOTO M: "Repression via the GATA box is essential for tissue-specific erythropoietin gene expression", BLOOD, vol. 111, 2008, pages 5223 - 5232, XP055125443, DOI: doi:10.1182/blood-2007-10-115857
MORITA M. ET AL., EMBO J., vol. 22, no. 5, 2003, pages 1134 - 1146
TAKAHASHI S. ET AL., M. J. BIOL. CHEM., vol. 272, no. 19, 1997, pages 12611 - 12615
IMAGAWA S ET AL., INT. J. HEMATOL., vol. 75, no. 4, 2002, pages 376 - 381
See also references of EP 2695515A4
Attorney, Agent or Firm:
OHNO, Seiji et al. (JP)
Seiji Ono (JP)
Seiji Ono (JP)
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