Title:
GROUP B STREPTOCOCCAL PHAGE LYSIN
Document Type and Number:
WIPO Patent Application WO2004020451
Kind Code:
A9
Abstract:
The present disclosure relates to the identification of the phage lysine from group B streptococci (GBS). The nucleic acid sequence and amino acid sequence of the GBS phage lysine is disclosed. The GBS phage lysine is a unique bifunctional protein comprising a glucosidase and an endopeptidease activity. The endopeptidease present in the GBS phage lysis has a substrate specificity that has not been previously reported. The bifunctional GBS phage lysine is effective against groups A, B, C, E and G streptococci. Also described are methods of using the GBS phage lysine for the prevention and treatment of bacterial infections.
Inventors:
PRITCHARD DAVID
BAKER JOHN
SCHWEBKE JANE
ENGLER JEFFREY
BAKER JOHN
SCHWEBKE JANE
ENGLER JEFFREY
Application Number:
PCT/US2003/027090
Publication Date:
June 03, 2004
Filing Date:
August 28, 2003
Export Citation:
Assignee:
UAB RESEARCH FOUNDATION (US)
International Classes:
C07H21/04; C12N9/50; C12P21/04; A61K38/00; A61K39/00; (IPC1-7): C07H21/04; A61K38/00; A61K39/09; A61K39/02; C07K1/00; C07K2/00; C12N15/00; C12N15/09; C12P21/04; C12P21/06
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