Title:
HCN POLYPEPTIDES AND POLYNUCLEOTIDES AND THEIR USE IN THERAPY
Document Type and Number:
WIPO Patent Application WO2002002630
Kind Code:
A3
Abstract:
The invention relates to newly identified uses of HCN channel polypeptides and polynucleotides encoding such polypeptides, to their use in therapy and in identifying compounds which may be antagonists and/or inhibitors which are potentially useful in therapy, and to production of such polypeptides and polynucleotides.
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Inventors:
STRIJBOS PAUL JOHANNES LEONARD (GB)
BATES STEWART (GB)
GLOGER ISRO (GB)
DAVIES CERI (GB)
BATES STEWART (GB)
GLOGER ISRO (GB)
DAVIES CERI (GB)
Application Number:
PCT/GB2001/002959
Publication Date:
October 24, 2002
Filing Date:
July 03, 2001
Export Citation:
Assignee:
SMITHKLINE BEECHAM PLC (GB)
STRIJBOS PAUL JOHANNES LEONARD (GB)
BATES STEWART (GB)
GLOGER ISRO (GB)
DAVIES CERI (GB)
STRIJBOS PAUL JOHANNES LEONARD (GB)
BATES STEWART (GB)
GLOGER ISRO (GB)
DAVIES CERI (GB)
International Classes:
C07K14/705; A61K38/00; (IPC1-7): C07K14/705; C12N15/11; C12N5/10; A61K31/00; A61K38/00
Domestic Patent References:
| WO1999032615A1 | 1999-07-01 | |||
| WO1999042574A1 | 1999-08-26 | |||
| WO1999018941A2 | 1999-04-22 |
Other References:
DATABASE GENBANK 29 May 1998 (1998-05-29), SANTORO B ET AL: "Homo sapiens ion channel BCNG-1 mRNA", XP002177237
DATABASE EMBL 7 May 1999 (1999-05-07), LUDWIG A: "Homo sapiens mRNA for hyperpolarisation-activated cation channel HCN2", XP002184184
DATABASE EMBL 7 May 1999 (1999-05-07), LUDWIG A: "Homo sapiens mRNA for hyperpolarisation-activated, cyclic nucleotide-gated cation channel hHCN4", XP002184185
LUDWIG ANDREAS ET AL: "Two pacemaker channels from human heart with profoundly different activation kinetics.", EMBO (EUROPEAN MOLECULAR BIOLOGY ORGANIZATION) JOURNAL, vol. 18, no. 9, 4 May 1999 (1999-05-04), pages 2323 - 2329, XP002177235, ISSN: 0261-4189
DATABASE EMBL 10 June 1998 (1998-06-10), VACCARI T ET AL: "Homo sapiens hyperpolarisation-activated, cyclic nucleotide-gated channel 2 (HCN2) mRNA", XP002184186
DATABASE EMBL 13 August 1999 (1999-08-13), SEIFERT R ET AL: "Homo sapiens mRNA for hyperpolarisation-activated channel type 4 (HCN4)", XP002184187
SEIFERT REINHARD ET AL: "Molecular characterization of a slowly gating human hyperpolarization-activated channel predominantly expressed in thalamus, heart, and testis.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES, vol. 96, no. 16, 3 August 1999 (1999-08-03), Aug. 3, 1999, pages 9391 - 9396, XP002177236, ISSN: 0027-8424
DATABASE EMBL 23 May 2000 (2000-05-23), NAGASE T ET AL: "Homo sapiens mRNA for KIAA1535 protein", XP002184188
SANTORO BINA ET AL: "The HCN gene family: Molecular basis of the hyperpolarization-activa ted pacemaker channels.", ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, vol. 868, 30 April 1999 (1999-04-30), pages 741 - 764, XP002177233, ISBN: 1-57331-177-4
CLAPHAM DAVID E: "Not so funny anymore: Pacing channels are cloned.", NEURON, vol. 21, no. 1, July 1998 (1998-07-01), pages 5 - 7, XP002177234, ISSN: 0896-6273
HARRIS N C ET AL: "Mechanism of Block by ZD 7288 of the Hyoerpolarization-Activated Inward Rectifying Current in Guinea Pig Substantia Nigra Neurons In Vitro", JOURNAL OF NEUROPHYSIOLOGY, vol. 74, no. 6, December 1995 (1995-12-01), pages 2366 - 2378, XP002108866
DATABASE EMBL 7 May 1999 (1999-05-07), LUDWIG A: "Homo sapiens mRNA for hyperpolarisation-activated cation channel HCN2", XP002184184
DATABASE EMBL 7 May 1999 (1999-05-07), LUDWIG A: "Homo sapiens mRNA for hyperpolarisation-activated, cyclic nucleotide-gated cation channel hHCN4", XP002184185
LUDWIG ANDREAS ET AL: "Two pacemaker channels from human heart with profoundly different activation kinetics.", EMBO (EUROPEAN MOLECULAR BIOLOGY ORGANIZATION) JOURNAL, vol. 18, no. 9, 4 May 1999 (1999-05-04), pages 2323 - 2329, XP002177235, ISSN: 0261-4189
DATABASE EMBL 10 June 1998 (1998-06-10), VACCARI T ET AL: "Homo sapiens hyperpolarisation-activated, cyclic nucleotide-gated channel 2 (HCN2) mRNA", XP002184186
DATABASE EMBL 13 August 1999 (1999-08-13), SEIFERT R ET AL: "Homo sapiens mRNA for hyperpolarisation-activated channel type 4 (HCN4)", XP002184187
SEIFERT REINHARD ET AL: "Molecular characterization of a slowly gating human hyperpolarization-activated channel predominantly expressed in thalamus, heart, and testis.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES, vol. 96, no. 16, 3 August 1999 (1999-08-03), Aug. 3, 1999, pages 9391 - 9396, XP002177236, ISSN: 0027-8424
DATABASE EMBL 23 May 2000 (2000-05-23), NAGASE T ET AL: "Homo sapiens mRNA for KIAA1535 protein", XP002184188
SANTORO BINA ET AL: "The HCN gene family: Molecular basis of the hyperpolarization-activa ted pacemaker channels.", ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, vol. 868, 30 April 1999 (1999-04-30), pages 741 - 764, XP002177233, ISBN: 1-57331-177-4
CLAPHAM DAVID E: "Not so funny anymore: Pacing channels are cloned.", NEURON, vol. 21, no. 1, July 1998 (1998-07-01), pages 5 - 7, XP002177234, ISSN: 0896-6273
HARRIS N C ET AL: "Mechanism of Block by ZD 7288 of the Hyoerpolarization-Activated Inward Rectifying Current in Guinea Pig Substantia Nigra Neurons In Vitro", JOURNAL OF NEUROPHYSIOLOGY, vol. 74, no. 6, December 1995 (1995-12-01), pages 2366 - 2378, XP002108866
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