Title:
HepNaDC GENE
Document Type and Number:
WIPO Patent Application WO/2003/029465
Kind Code:
A1
Abstract:
Sodium di− or tricarboxylate cotransporter gene (HepNaDC gene) expressed in human hepatocyte cancer−origin cells HepG2, for example, a DNA molecule containing a polynucleotide encoding a polypeptide comprising the amino acid sequence represented by SEQ ID NO:1&semi its expression vector&semi host cells carrying the same&semi expression product produced by the cells&semi an antibody against the expression product&semi drugs containing the antibody as the active ingredient, etc. Using this gene, it becomes possible to produce HepNaDC polypeptide, an antibody against it as an antigen, etc. Moreover, the biological activity of the HepNaDC polypeptide can be inhibited so that a candidate compound useful in preventing&sol treating diabetes or obesity or controlling calorie intake can be screened.
Inventors:
KANEMOTO NAOHIDE (JP)
OMORI YOSHIHIRO (JP)
SUGANO SUMIO (JP)
OBUCHI YUTAKA (JP)
OMORI YOSHIHIRO (JP)
SUGANO SUMIO (JP)
OBUCHI YUTAKA (JP)
Application Number:
PCT/JP2002/010038
Publication Date:
April 10, 2003
Filing Date:
September 27, 2002
Export Citation:
Assignee:
OTSUKA PHARMA CO LTD (JP)
KANEMOTO NAOHIDE (JP)
OMORI YOSHIHIRO (JP)
SUGANO SUMIO (JP)
OBUCHI YUTAKA (JP)
KANEMOTO NAOHIDE (JP)
OMORI YOSHIHIRO (JP)
SUGANO SUMIO (JP)
OBUCHI YUTAKA (JP)
International Classes:
C12N15/09; A61K31/7088; A61K35/76; A61K45/00; A61K48/00; A61P1/00; A61P1/16; A61P3/04; A61P3/06; A61P3/10; A61P5/48; A61P39/06; A61P43/00; C07K14/47; C07K16/18; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/12; (IPC1-7): C12N15/12; A61K38/17; A61K39/395; A61P1/00; A61P5/48; C07K14/47; C07K16/18; C12N5/10
Foreign References:
| US20020019028A1 | 2002-02-14 |
Other References:
PAJOR A.M. ET AL.: "Molecular cloning and functional expression of a sodium-dicarboxylate cotransporter from human kidney", AM. J. PHYSIOL., vol. 270, no. 4, PT. 2, 1996, pages F642 - F648, XP002961004
PAJOR A.M. ET AL.: "Sequence and functional characterization of a renal sodium/dicarboxylate cotransporter", J. BIOL. CHEM., vol. 270, no. 11, 1995, pages 5779 - 5785, XP002961005
PAJOR A.M. ET AL.: "Sequence and functional characterization of a renal sodium/dicarboxylate cotransporter", J. BIOL. CHEM., vol. 270, no. 11, 1995, pages 5779 - 5785, XP002961005
Attorney, Agent or Firm:
The, Patent Corporate Body Aruga Patent Office (3-6 NIHONBASHININGYOCHO 1-CHOM, CHUO-KU Tokyo, JP)
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