GENES ASSOCIATED WITH MAST CELL ACTIVATION

Title:

GENES ASSOCIATED WITH MAST CELL ACTIVATION

Document Type and Number:

WIPO Patent Application WO2003029464

Kind Code:

A3

Abstract:

The invention relates generally to the changes in gene expression in mast cells and tissues removed from patients with allergic hypersensitivity. The invention specifically relates to the genes MC21, MC22, MC25, MC33, MC36, and MC39, which are differentially expressed in mast cells compared to normal tissues and in resting mast cells versus activated mast cells.

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Inventors:

NOCKA KARL (US)
MEDLEY QUINTUS (US)
THOMIS DANIEL (US)
GU JESSIE (US)
LU SUN (US)

Application Number:

PCT/EP2002/010897

Publication Date:

November 27, 2003

Filing Date:

September 27, 2002

Export Citation:

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Assignee:

UCB SA (BE)
NOCKA KARL (US)
MEDLEY QUINTUS (US)
THOMIS DANIEL (US)
GU JESSIE (US)
LU SUN (US)

International Classes:

A01K67/027; A61K45/00; A61P37/00; A61P37/08; C07K14/47; C07K14/705; C07K16/28; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/09; C12N15/12; C12P21/02; C12P21/08; C12Q1/02; C12Q1/68; (IPC1-7): C12N15/12; A01K67/027; A61P37/00; C07K14/705; C07K16/28; C12Q1/68; G01N33/50

Domestic Patent References:

WO2001023523A2	2001-04-05
WO2000045843A1	2000-08-10

Other References:

SAITO HIROHISA ET AL: "Human mast cell transcriptome project.", INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY, vol. 125, no. 1, May 2001 (2001-05-01), pages 1 - 8, XP008012793, ISSN: 1018-2438
CHEN HUAXIAN ET AL: "Characterization of gene expression in resting and activated mast cells.", JOURNAL OF EXPERIMENTAL MEDICINE, vol. 188, no. 9, 2 November 1998 (1998-11-02), pages 1657 - 1668, XP002229484, ISSN: 0022-1007
SAYAMA KOICHI ET AL: "Transcriptional response of human mast cells stimulated via the FcepsilonRI and identification of mast cells as a source of IL-11.", BMC IMMUNOLOGY, vol. 3, no. 5 Cited July 8, 2002, 12 June 2002 (2002-06-12), June 12, 2002, pages No Pagination, XP002229485, ISSN: 1471-2172

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