Title:
HETEROCYCLIC COMPOUND
Document Type and Number:
WIPO Patent Application WO/2014/142255
Kind Code:
A1
Abstract:
Provided is a heterocyclic compound exhibiting an RORγt-inhibiting action. Specifically provided is a compound represented by formula (I) or a salt thereof. [In the formula, Ar indicates partial formulas (1) through (5), Q indicates a bivalent group selected from the group consisting of (Ia) through (If), and B indicates an optionally substituted ring.]
Inventors:
YAMAMOTO SATOSHI (JP)
SHIRAI JUNYA (JP)
FUKASE YOSHIYUKI (JP)
SATO AYUMU (JP)
KOUNO MITSUNORI (JP)
TOMATA YOSHIHIDE (JP)
OCHIDA ATSUKO (JP)
YONEMORI KAZUKO (JP)
ODA TSUNEO (JP)
IMADA TAKASHI (JP)
YUKAWA TOMOYA (JP)
SHIRAI JUNYA (JP)
FUKASE YOSHIYUKI (JP)
SATO AYUMU (JP)
KOUNO MITSUNORI (JP)
TOMATA YOSHIHIDE (JP)
OCHIDA ATSUKO (JP)
YONEMORI KAZUKO (JP)
ODA TSUNEO (JP)
IMADA TAKASHI (JP)
YUKAWA TOMOYA (JP)
Application Number:
PCT/JP2014/056721
Publication Date:
September 18, 2014
Filing Date:
March 13, 2014
Export Citation:
Assignee:
TAKEDA PHARMACEUTICAL (JP)
International Classes:
C07D239/80; A61K31/437; A61K31/517; A61K31/519; A61K31/538; A61K31/5386; A61P1/04; A61P17/06; A61P25/00; A61P29/00; A61P37/06; A61P43/00; C07D239/96; C07D265/36; C07D401/12; C07D403/12; C07D409/12; C07D413/12; C07D417/12; C07D471/04
Domestic Patent References:
| WO2001044228A2 | 2001-06-21 | |||
| WO2006064286A1 | 2006-06-22 | |||
| WO2001044228A2 | 2001-06-21 | |||
| WO2010142752A1 | 2010-12-16 |
Foreign References:
| JPS57209281A | 1982-12-22 | |||
| US20060135557A1 | 2006-06-22 |
Other References:
JONES, G.H. ET AL.: "Inhibitors of cyclic AMP phosphodiesterase. 1. Analogs of cilostamide and anagrelide", JOURNAL OF MEDICINAL CHEMISTRY, vol. 30, no. 2, 1987, pages 295 - 303, XP000941984
VENUTI, M.C. ET AL.: "Inhibitors of cyclic AMP phosphodiesterase. 4 . Synthesis and evaluation of potential prodrugs of lixazinone(N- cyclohexyl-N-methyl-4-[(1,2,3,5-tetrahydro-2- oxoimidazo[2,1- b]quinazolin-7-yl)oxy] butyramide, RS-82856", JOURNAL OF MEDICINAL CHEMISTRY, vol. 31, no. 11, 1988, pages 2145 - 2152, XP000872883
CHEN, Y. ET AL.: "Design, Synthesis, and Biological Evaluation of Isoquinoline-1,3,4- trione Derivatives as Potent Caspase-3 Inhibitors", JOURNAL OF MEDICINAL CHEMISTRY, vol. 49, no. 5, 2006, pages 1613 - 1623, XP055283676
DU, J. ET AL.: "Isoquinoline-1,3,4-trione Derivatives Inactivate Caspase-3 by Generation of Reactive Oxygen Species", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 283, no. 44, 2008, pages 30205 - 30215, XP055283677
See also references of EP 2975031A4
THEODORA W. GREENE; PETER G. M. WUTS: "Protective Groups in Organic Synthesis", 1999, WILEY-INTERSCIENCE, INC.
"Jikken Kagaku Kouza, 4th Edition, vol.20, organic synthesis II", vol. 20, 1991, CHEMICAL SOCIETY OF JAPAN
THEODORA W. GREENE; PETER G. M. WUTS: "Protective Groups in Organic Synthesis", 1999, WILEY-INTERSCIENCE, INC
"Molecule Design", vol. 7, 1990, HIROKAWA SHOTEN, article "Development of Pharmaceutical Products", pages: 163 - 198
"Journal of Antibiotics", J. ANTIBIOTICS, vol. 38, 1985, pages 877 - 885
"Chemical and Pharmaceutical Bulletin", CHEM. PHARM. BULL, vol. 38, 1990, pages 2792 - 2796
VENUTI, M.C. ET AL.: "Inhibitors of cyclic AMP phosphodiesterase. 4 . Synthesis and evaluation of potential prodrugs of lixazinone(N- cyclohexyl-N-methyl-4-[(1,2,3,5-tetrahydro-2- oxoimidazo[2,1- b]quinazolin-7-yl)oxy] butyramide, RS-82856", JOURNAL OF MEDICINAL CHEMISTRY, vol. 31, no. 11, 1988, pages 2145 - 2152, XP000872883
CHEN, Y. ET AL.: "Design, Synthesis, and Biological Evaluation of Isoquinoline-1,3,4- trione Derivatives as Potent Caspase-3 Inhibitors", JOURNAL OF MEDICINAL CHEMISTRY, vol. 49, no. 5, 2006, pages 1613 - 1623, XP055283676
DU, J. ET AL.: "Isoquinoline-1,3,4-trione Derivatives Inactivate Caspase-3 by Generation of Reactive Oxygen Species", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 283, no. 44, 2008, pages 30205 - 30215, XP055283677
See also references of EP 2975031A4
THEODORA W. GREENE; PETER G. M. WUTS: "Protective Groups in Organic Synthesis", 1999, WILEY-INTERSCIENCE, INC.
"Jikken Kagaku Kouza, 4th Edition, vol.20, organic synthesis II", vol. 20, 1991, CHEMICAL SOCIETY OF JAPAN
THEODORA W. GREENE; PETER G. M. WUTS: "Protective Groups in Organic Synthesis", 1999, WILEY-INTERSCIENCE, INC
"Molecule Design", vol. 7, 1990, HIROKAWA SHOTEN, article "Development of Pharmaceutical Products", pages: 163 - 198
"Journal of Antibiotics", J. ANTIBIOTICS, vol. 38, 1985, pages 877 - 885
"Chemical and Pharmaceutical Bulletin", CHEM. PHARM. BULL, vol. 38, 1990, pages 2792 - 2796
Attorney, Agent or Firm:
TAKASHIMA, HAJIME (JP)
Takashima 1 (JP)
Takashima 1 (JP)
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