Title:
HUMAN TRANSPORT PROTEIN HOMOLOGS
Document Type and Number:
WIPO Patent Application WO2000003015
Kind Code:
A3
Abstract:
The invention provides a human transport protein homologs (HTPH) and polynucleotides which identify and encode HTPH. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating or preventing disorders associated with expression of HTPH.
Inventors:
HILLMAN JENNIFER L (US)
YUE HENRY (US)
REDDY ROOPA M (US)
GORGONE GINA A (US)
CORLEY NEIL C (US)
AZIMZAI YALDA (US)
PATTERSON CHANDRA (US)
BAUGHN MARIAH R (US)
YUE HENRY (US)
REDDY ROOPA M (US)
GORGONE GINA A (US)
CORLEY NEIL C (US)
AZIMZAI YALDA (US)
PATTERSON CHANDRA (US)
BAUGHN MARIAH R (US)
Application Number:
PCT/US1999/015482
Publication Date:
April 13, 2000
Filing Date:
July 08, 1999
Export Citation:
Assignee:
INCYTE PHARMA INC (US)
HILLMAN JENNIFER L (US)
YUE HENRY (US)
REDDY ROOPA M (US)
GORGONE GINA A (US)
CORLEY NEIL C (US)
AZIMZAI YALDA (US)
PATTERSON CHANDRA (US)
BAUGHN MARIAH R (US)
HILLMAN JENNIFER L (US)
YUE HENRY (US)
REDDY ROOPA M (US)
GORGONE GINA A (US)
CORLEY NEIL C (US)
AZIMZAI YALDA (US)
PATTERSON CHANDRA (US)
BAUGHN MARIAH R (US)
International Classes:
G01N33/53; A61K31/7088; A61K38/00; A61K39/395; A61K45/00; A61P3/00; A61P15/00; A61P35/00; A61P43/00; C07K14/47; C07K14/705; C07K16/18; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/09; C12N15/12; C12P21/02; C12Q1/68; G01N33/68; (IPC1-7): C12N15/12; C07K14/705; A61K38/17; A61K35/00; C07K16/28; C12N15/11; A61K31/70; A61K39/395; C12Q1/68; G01N33/68
Other References:
FURUYA K.N. ET AL.: "Identification of a new P-glycoprotein-like ATP-binding cassette transporter gene that is overexpressed during hepatocarcinogenesis", CANCER RESEARCH, vol. 57, 1 September 1997 (1997-09-01), AMERICAN ASSOCIATION FOR CANCER RESEARCH, BALTIMORE, MD, US, pages 3708 - 3716, XP002120399, ISSN: 0008-5472
ALLIKMETS R. ET AL.: "Characterization of the human ABC superfamily: isolation and mapping of 21 new genes using the Expressed Sequence Tags Database", HUMAN MOLECULAR GENETICS, vol. 5, no. 10, 1996, OXFORD UNIVERSITY PRESS, SURREY, GB, pages 1649 - 1655, XP002120400, ISSN: 0964-6906
DATABASE EMBL NUCLEOTIDE SEQU 1 January 1900 (1900-01-01), XP002120402, Database accession no. R49046
DATABASE EMBL NUCLEOTIDE SEQU 1 January 1900 (1900-01-01), XP002120403, Database accession no. AJ003004
HIRSCH-ERNST K.I. ET AL.: "Molecular cDNA cloning and tissue distribution of mRNA encoding a novel ATP-binding cassette (ABC) half-transporter", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 249, no. 1, 10 August 1998 (1998-08-10), ACADEMIC PRESS INC. ORLANDO, FL, US, pages 151 - 155, XP002120401, ISSN: 0006-291X
DATABASE EMBL NUCLEOTIDE SEQU 1 January 1900 (1900-01-01), XP002120404, Database accession no. AF070598
SAVARY S. ET AL.: "Isolation and chromosomal mapping of a novel ATP-Binding Cassette Transporter conserved in mouse and human", GENOMICS, vol. 41, no. 2, 15 April 1997 (1997-04-15), SAN DIEGO, US, pages 275 - 278, XP002083182, ISSN: 0888-7543
MOSSER J. ET AL.: "Putative X-linked Adrenoleukodystrophy gene shares unexpected homology with ABC Transporters", NATURE, vol. 361, 25 February 1993 (1993-02-25), pages 726 - 730, XP002005763, ISSN: 0028-0836
HOLZINGER A. ET AL.: "cDNA cloning and mRNA expression of the human adrenoleukodystrophy related protein (ALDRP), a peroxisomal ABC transporter", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 239, no. 1, 9 October 1997 (1997-10-09), pages 261 - 264, XP002091087, ISSN: 0006-291X
HOLZINGER A. ET AL.: "Primary structure of human PMP69, a putative peroxisomal ABC-transporter", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 237, no. 1, 8 August 1997 (1997-08-08), pages 152 - 157, XP002091088, ISSN: 0006-291X
ALLIKMETS R. ET AL.: "Characterization of the human ABC superfamily: isolation and mapping of 21 new genes using the Expressed Sequence Tags Database", HUMAN MOLECULAR GENETICS, vol. 5, no. 10, 1996, OXFORD UNIVERSITY PRESS, SURREY, GB, pages 1649 - 1655, XP002120400, ISSN: 0964-6906
DATABASE EMBL NUCLEOTIDE SEQU 1 January 1900 (1900-01-01), XP002120402, Database accession no. R49046
DATABASE EMBL NUCLEOTIDE SEQU 1 January 1900 (1900-01-01), XP002120403, Database accession no. AJ003004
HIRSCH-ERNST K.I. ET AL.: "Molecular cDNA cloning and tissue distribution of mRNA encoding a novel ATP-binding cassette (ABC) half-transporter", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 249, no. 1, 10 August 1998 (1998-08-10), ACADEMIC PRESS INC. ORLANDO, FL, US, pages 151 - 155, XP002120401, ISSN: 0006-291X
DATABASE EMBL NUCLEOTIDE SEQU 1 January 1900 (1900-01-01), XP002120404, Database accession no. AF070598
SAVARY S. ET AL.: "Isolation and chromosomal mapping of a novel ATP-Binding Cassette Transporter conserved in mouse and human", GENOMICS, vol. 41, no. 2, 15 April 1997 (1997-04-15), SAN DIEGO, US, pages 275 - 278, XP002083182, ISSN: 0888-7543
MOSSER J. ET AL.: "Putative X-linked Adrenoleukodystrophy gene shares unexpected homology with ABC Transporters", NATURE, vol. 361, 25 February 1993 (1993-02-25), pages 726 - 730, XP002005763, ISSN: 0028-0836
HOLZINGER A. ET AL.: "cDNA cloning and mRNA expression of the human adrenoleukodystrophy related protein (ALDRP), a peroxisomal ABC transporter", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 239, no. 1, 9 October 1997 (1997-10-09), pages 261 - 264, XP002091087, ISSN: 0006-291X
HOLZINGER A. ET AL.: "Primary structure of human PMP69, a putative peroxisomal ABC-transporter", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 237, no. 1, 8 August 1997 (1997-08-08), pages 152 - 157, XP002091088, ISSN: 0006-291X
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