Title:
HUMAN TYPE COMPLEMENTATION-DETERMINING DOMAIN TRANSPLANTED ANTIBODY AGAINST GANGLIOSIDE GD2 AND DERIVATIVE OF THIS ANTIBODY
Document Type and Number:
WIPO Patent Application WO/2001/023573
Kind Code:
A1
Abstract:
A monoclonal antibody against ganglioside GD2 having a novel complementation-determining domain to ganglioside GD2; a fused protein of this antibody with a cytokine; and therapeutic and diagnostic uses of the above-described antibody and fused protein.
Inventors:
HANAI NOBUO (JP)
SHITARA KENYA (JP)
NAKAMURA KAZUYASU (JP)
NIWA RINPEI (JP)
SHITARA KENYA (JP)
NAKAMURA KAZUYASU (JP)
NIWA RINPEI (JP)
Application Number:
PCT/JP2000/006773
Publication Date:
April 05, 2001
Filing Date:
September 29, 2000
Export Citation:
Assignee:
KYOWA HAKKO KOGYO KK (JP)
HANAI NOBUO (JP)
SHITARA KENYA (JP)
NAKAMURA KAZUYASU (JP)
NIWA RINPEI (JP)
HANAI NOBUO (JP)
SHITARA KENYA (JP)
NAKAMURA KAZUYASU (JP)
NIWA RINPEI (JP)
International Classes:
A61P35/00; C07K16/18; C12N15/13; C12P21/08; A61K38/00; (IPC1-7): C12N15/13; A61K39/395; A61P35/00; C07K16/18; C07K19/00; C12N5/10; C12P21/08; G01N33/557; G01N33/566
Domestic Patent References:
| WO1997034634A1 | 1997-09-25 |
Other References:
BARBARA M. ET AL.: "Enhancement of antibody-dependent cytotoxicity with a chimeric anti-GD2 antibody", THE JOURNAL OF IMMUNOLOGY, vol. 144, no. 4, 1990, pages 1382 - 1386, XP002934990
SO OHTA ET AL.: "Cytotoxicity of adrinamycin-containing immunoliposomes targeted with anti-ganglioside monoclonal antibodies", ANTICANCER RESEARCH, vol. 13, no. 2, 1993, pages 331 - 336, XP002934991
OSAMU KANEMITSU: "Koutai Kougaku Nyuumon", 25 January 1994, CHIJIN SHOKAN, XP002934992
SO OHTA ET AL.: "Cytotoxicity of adrinamycin-containing immunoliposomes targeted with anti-ganglioside monoclonal antibodies", ANTICANCER RESEARCH, vol. 13, no. 2, 1993, pages 331 - 336, XP002934991
OSAMU KANEMITSU: "Koutai Kougaku Nyuumon", 25 January 1994, CHIJIN SHOKAN, XP002934992
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