Title:
HYPOTENSORS
Document Type and Number:
WIPO Patent Application WO/2001/077673
Kind Code:
A1
Abstract:
A method of selecting a substance capable of controlling the activation of prorenin with the use of, as an indication, the ability to control the activation of prorenin by an interaction between proteins in the profragment domain of prorenin; a prorenin activation controlling substance which has a function of controlling the activation of prorenin based on the interaction between proteins in the profragment domain of prorenin; and hypotensors, organ overgrowth inhibitors and arterial thickening inhibitors containing the above-described prorenin activation controlling substance as the active ingredient.
Inventors:
ISHIDA YUICHI (JP)
SUZUKI FUMIAKI (JP)
MURAKAMI KAZUO (JP)
SUZUKI FUMIAKI (JP)
MURAKAMI KAZUO (JP)
Application Number:
PCT/JP2001/003034
Publication Date:
October 18, 2001
Filing Date:
April 09, 2001
Export Citation:
Assignee:
ISHIDA YUICHI (JP)
SUZUKI FUMIAKI (JP)
MURAKAMI KAZUO (JP)
SUZUKI FUMIAKI (JP)
MURAKAMI KAZUO (JP)
International Classes:
A61P9/12; C07K14/47; C12N9/64; C12Q1/37; A61K38/00; (IPC1-7): G01N33/50; G01N33/15; C07K5/08; C07K5/10; C07K7/06; C07K7/08; A61P9/12; A61K38/04
Foreign References:
| EP0873999A1 | 1998-10-28 | |||
| JP2000186100A | 2000-07-04 |
Other References:
DUBIN D. ET AL.: "Synthetic peptide inhibitors of prorenin activation", J. HYPERTENS., vol. 7, no. SUPPL. 2, 1989, SYMPOSIUM OF RENIN INHIBITORS: PRESENT AND FUTURE HELD AT THE 12TH SCIENTIFIC MEETING OF THE INTERNATIONAL SOCIETY OF HYPERTENSION, OSAKA, JAPAN, 28 MAY 1988, pages S71 - S74, XP002942253
CLINICAL CHEMISTRY, vol. 42, 1996, pages 1051 - 1063, XP002942254
See also references of EP 1273914A4
CLINICAL CHEMISTRY, vol. 42, 1996, pages 1051 - 1063, XP002942254
See also references of EP 1273914A4
Attorney, Agent or Firm:
Shoji, Takashi (Iwamotocho 3-chome Chiyoda-ku, Tokyo, JP)
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