Title:
IMMUNOGENIC LIBRARY OF CHIMERIC PEPTIDES MIMICKING THE GENETIC DIVERSITY OF THE HYPERVARIABLE REGION V3 OF THE PROTEIN OF THE ENVELOPE OF A VIRUS GP 120 OF HUMAN IMMUNODEFICIENCY
Document Type and Number:
WIPO Patent Application WO/2004/031226
Kind Code:
A1
Abstract:
The invention relates to medicine and biotechnology, in particular to the diagnosis and preventive vaccination against AIDS-1 and can be used for producing antigens for diagnostic test-systems and for producing a vaccine against AIDS-1. The inventive immunogenic library of chimeric peptides mimicking the genetic diversity of the hypervariable region V3 gp120 AIDS-1 is embodied in such a way that it is immunogenic, initiates the production of antibodies interacting with a wide spectrum of gp120 variants of various genotypes of AIDS-1 and exhibits the capacity to bind earlier antibodies to AIDS-1. The structural composition of the library is disclosed in the description thereof. The capacity of the immunologic library of chimeric peptides to bind specific antibodies against AIDS-1 is studied with the aid of the indirect variant of an immunoassay analysis of the serum of AIDS-1 infected persons in comparison with the serum of healthy persons and the serum of standard anti- AIDS-1 panels. The immunisation of laboratory animals by the library of chimeric peptides produces specific antibodies interacting with a wide spectrum of gp 120 variants of various genotypes of human immunodeficiency.
Inventors:
MAKSYUTOV AMIR ZAKIEVICH (RU)
KOLOBOV ALEKSANDR ALEKSANDROVI (RU)
RYZHIKOV ALEKSANDR BORISOVICH (RU)
KANEV ALEKSANDR NIKOLAEVICH (RU)
MAKSYUTOV ZAKI AMIROVICH (RU)
KOLOBOV ALEKSANDR ALEKSANDROVI (RU)
RYZHIKOV ALEKSANDR BORISOVICH (RU)
KANEV ALEKSANDR NIKOLAEVICH (RU)
MAKSYUTOV ZAKI AMIROVICH (RU)
Application Number:
PCT/RU2003/000423
Publication Date:
April 15, 2004
Filing Date:
September 29, 2003
Export Citation:
Assignee:
G NAUCHNY TS VIRUSOLOGII BIOTE (RU)
MAKSYUTOV AMIR ZAKIEVICH (RU)
KOLOBOV ALEKSANDR ALEKSANDROVI (RU)
RYZHIKOV ALEKSANDR BORISOVICH (RU)
KANEV ALEKSANDR NIKOLAEVICH (RU)
MAKSYUTOV ZAKI AMIROVICH (RU)
MAKSYUTOV AMIR ZAKIEVICH (RU)
KOLOBOV ALEKSANDR ALEKSANDROVI (RU)
RYZHIKOV ALEKSANDR BORISOVICH (RU)
KANEV ALEKSANDR NIKOLAEVICH (RU)
MAKSYUTOV ZAKI AMIROVICH (RU)
International Classes:
C07K14/155; A61K39/21; A61P31/12; A61P31/18; C07K1/04; C07K14/02; C07K14/11; C07K14/16; C07K14/18; C07K14/35; C07K14/445; A61K38/00; A61K39/00; (IPC1-7): C07K14/155; A61K39/21; A61P31/18
Foreign References:
| US6042836A | 2000-03-28 |
Other References:
ESTAQUIER J. ET AL.: "The mixotope: a comnbinatorial peptide library as a T cell and B cell immunogen", EUR. J. IMMUNOL., vol. 24, no. 11, 1994, pages 2789 - 2795
CARLOS M. P. ET AL.: "Immunogenicity of a vaccine preparation representing the variable regions of the HIV type 1 envelope glycoprotein", AIDS RESHUM RETROVIRUSES, vol. 16, no. 2, 20 January 2000 (2000-01-20), pages 153 - 161
CARLOS M. P. ET AL.: "Immunogenicity of a vaccine preparation representing the variable regions of the HIV type 1 envelope glycoprotein", AIDS RESHUM RETROVIRUSES, vol. 16, no. 2, 20 January 2000 (2000-01-20), pages 153 - 161
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