Title:
INHIBITORS OF APOPTOSIS PROTEINS IN PLANTS
Document Type and Number:
WIPO Patent Application WO1999047689
Kind Code:
A3
Abstract:
This invention relates to an isolated nucleic acid fragment encoding an apoptosis inhibitory protein. The invention also relates to the construction of a chimeric gene encoding all or a portion of the apoptosis inhibitory protein, in sense or antisense orientation, wherein expression of the chimeric gene results in production of altered levels of the apoptosis inhibitory protein in a transformed host cell.
More Like This:
Inventors:
CAHOON REBECCA E (US)
CAIMI PERRY G (US)
KLEIN THEODORE M (US)
MORGANTE MICHELE (US)
SAKAI HAJIME (US)
SHEN JENNIE BIH-JIEN (US)
TINGEY SCOTT V (US)
CAIMI PERRY G (US)
KLEIN THEODORE M (US)
MORGANTE MICHELE (US)
SAKAI HAJIME (US)
SHEN JENNIE BIH-JIEN (US)
TINGEY SCOTT V (US)
Application Number:
PCT/US1999/005227
Publication Date:
November 25, 1999
Filing Date:
March 10, 1999
Export Citation:
Assignee:
DU PONT (US)
CAHOON REBECCA E (US)
CAIMI PERRY G (US)
KLEIN THEODORE M (US)
MORGANTE MICHELE (US)
SAKAI HAJIME (US)
SHEN JENNIE BIH JIEN (US)
TINGEY SCOTT V (US)
CAHOON REBECCA E (US)
CAIMI PERRY G (US)
KLEIN THEODORE M (US)
MORGANTE MICHELE (US)
SAKAI HAJIME (US)
SHEN JENNIE BIH JIEN (US)
TINGEY SCOTT V (US)
International Classes:
C07K14/415; C12N15/29; C12N15/82; (IPC1-7): C12N15/82; C07K14/415; C12N5/10; C12N15/29; C12Q1/68
Other References:
TANAKA, Y., ET AL.: "dad-1, a putative programmed cell death suppressor gene in rice", PLANT CELL PHYSIOL., vol. 38, no. 3, 1997, pages 379 - 383, XP002085156
GALLOIS, P., ET AL.: "an Arabidopsis thaliana cDNA complementing a hamster apoptosis suppressor mutant", THE PLANT JOURNAL, vol. 11, no. 6, 1997, pages 1325 - 1331, XP002106087
ORZAEZ, D., ET AL.: "the plant homologue of the defender against apoptotic death gene is down-regulated during senescence of flower petals", FEBS LETTERS, vol. 404, 1997, pages 275 - 278, XP002106088
APTE, S.S., ET AL.: "the highly conserved defender against the death 1 (DAD1) gene maps to human chromosome 14q11-q12 and mouse chromosome 14 and has plant and nematode homologs", FEBS LETTERS, vol. 363, 1995, pages 304 - 306, XP002106089
SUGIMOTO, A., ET AL.: "dad-1, an endogenous programmed cell death suppressor in Caenorhabditis elegans and vertebrates", THE EMBO JOURNAL, vol. 14, no. 18, 1995, pages 4434 - 4441, XP002106090
KELLEHER, D., ET AL.: "DAD1, the defender against apoptotic cell death, is a subunit of the mammalian oligosaccharyltransferase", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE USA, vol. 94, May 1997 (1997-05-01), pages 4994 - 4999, XP002106091
MASTRANGELO A J ET AL: "Overcoming apoptosis: new methods for improving protein-expression systems", TRENDS IN BIOTECHNOLOGY, vol. 16, no. 2, 1 February 1998 (1998-02-01), pages 88-95, XP004107048
GALLOIS, P., ET AL.: "an Arabidopsis thaliana cDNA complementing a hamster apoptosis suppressor mutant", THE PLANT JOURNAL, vol. 11, no. 6, 1997, pages 1325 - 1331, XP002106087
ORZAEZ, D., ET AL.: "the plant homologue of the defender against apoptotic death gene is down-regulated during senescence of flower petals", FEBS LETTERS, vol. 404, 1997, pages 275 - 278, XP002106088
APTE, S.S., ET AL.: "the highly conserved defender against the death 1 (DAD1) gene maps to human chromosome 14q11-q12 and mouse chromosome 14 and has plant and nematode homologs", FEBS LETTERS, vol. 363, 1995, pages 304 - 306, XP002106089
SUGIMOTO, A., ET AL.: "dad-1, an endogenous programmed cell death suppressor in Caenorhabditis elegans and vertebrates", THE EMBO JOURNAL, vol. 14, no. 18, 1995, pages 4434 - 4441, XP002106090
KELLEHER, D., ET AL.: "DAD1, the defender against apoptotic cell death, is a subunit of the mammalian oligosaccharyltransferase", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE USA, vol. 94, May 1997 (1997-05-01), pages 4994 - 4999, XP002106091
MASTRANGELO A J ET AL: "Overcoming apoptosis: new methods for improving protein-expression systems", TRENDS IN BIOTECHNOLOGY, vol. 16, no. 2, 1 February 1998 (1998-02-01), pages 88-95, XP004107048
Download PDF:
Previous Patent: HUMAN MEKK PROTEINS, CORRESPONDING NUCLEIC ACID MOLECULES, AND USES THEREFOR
Next Patent: MULTIGENE VECTORS
Next Patent: MULTIGENE VECTORS