LIPOSOME COMPOSITION AND PROCESS FOR PRODUCTION THEREOF

WIPO Patent Application WO/2012/091054

A1

The purpose of the present invention is to provide a liposome composition into which a drug can be introduced in a high encapsulation amount, and which has sustained release properties to such an extent that the effective concentration can be maintained at a clinically satisfactory level, and which is suitable for subcutaneous administration or the like. This liposome composition comprises a first liposome which has an outer membrane composed of a multilayered lipid bilayer membrane and multiple second liposomes which are accommodated in a first liposome inner region that is defined by the outer membrane and each of which has an outer membrane composed of a multilayered lipid bilayer membrane, wherein the liposome composition has second liposome inner regions each defined by the outer membrane of each of the second liposome, and wherein ion gradient is formed at least between each of the second liposome inner regions and the outside of the first liposome.

JP2731976	INDUSTRIAL APPLICABILITY The drug composition acting on the microcirculation of the skin.
WO/2022/081548	IMPROVED PROCESS OF PREPARING ICE-BASED LIPID NANOPARTICLES
WO/2024/067816	PEGYLATED LIPID CONTAINING LYSINE CORE

YAMASHITA KEIKO (JP)
NOZAWA SHIGENORI (JP)

PCT/JP2011/080304

July 05, 2012

December 27, 2011

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TERUMO CORP (JP)
YAMASHITA KEIKO (JP)
NOZAWA SHIGENORI (JP)

A61K9/127; A61K47/24; A61K47/34; B01J13/02

WO2010058840A1	2010-05-27
WO2008050807A1	2008-05-02

JP2009132629A	2009-06-18
JP2010260828A	2010-11-18
JPH07173052A	1995-07-11
JP2001505224A	2001-04-17
JP2001522870A	2001-11-20

BIOMATERIALS, vol. 28, 2007, pages 1882 - 1888
ANESTHESIOLOGY, vol. 101, 2004, pages 133 - 137

WATANABE Mochitoshi et al. (JP)
Mochitoshi Watanabe (JP)

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