Title:
LOCO-REGIONAL PERFUSION OF A KIDNEY FOR LOCALIZED GENE THERAPY
Document Type and Number:
WIPO Patent Application WO/2024/074464
Kind Code:
A3
Abstract:
Disclosed is a method for treating a renal condition by loco-regional perfusion of one or both of a patient's kidneys. A closed circuit may be formed with a perfusion catheter positioned in the renal artery of the kidney, a recovery catheter positioned in the renal vein of the kidney, and an external membrane oxygenator disposed therebetween. A perfusate containing, for example, a gene therapy drug may be circulated through the closed circuit while isolating the closed circuit from the patient's systemic circulation.
More Like This:
| WO/1999/021882 | HBV BINDING POLYPEPTIDE |
| WO/2003/029461 | A METHOD OF GENETIC SCREENING USING AN AMPLIFIABLE GENE |
| JP2023510799 | Viral vectors for combination therapy |
Inventors:
EL ANDARI JOSEF (CH)
DEHDASHTIAN MARK (US)
AYUSO LÓPEZ ÉDUARD (CH)
GANJAM GOUTHAM KUMAR (CH)
RUSCONI CHRISTOPHER P (US)
DEHDASHTIAN MARK (US)
AYUSO LÓPEZ ÉDUARD (CH)
GANJAM GOUTHAM KUMAR (CH)
RUSCONI CHRISTOPHER P (US)
Application Number:
PCT/EP2023/077263
Publication Date:
May 30, 2024
Filing Date:
October 02, 2023
Export Citation:
Assignee:
DINAQOR AG (CH)
International Classes:
C12N15/86; A61K48/00; A61M25/00
Domestic Patent References:
| WO2022175546A1 | 2022-08-25 | |||
| WO2023056450A1 | 2023-04-06 | |||
| WO2022155435A1 | 2022-07-21 |
Other References:
RUBIN JEFFREY D. ET AL: "Improving Molecular Therapy in the Kidney", MOLECULAR DIAGNOSIS AND THERAPY, vol. 24, no. 4, 1 August 2021 (2021-08-01), NZ, pages 375 - 396, XP093117370, ISSN: 1177-1062, Retrieved from the Internet DOI: 10.1007/s40291-020-00467-6
ONUCHIC LAURA ET AL: "The C-terminal tail of polycystin-1 suppresses cystic disease in a mitochondrial enzyme-dependent fashion", BIORXIV, 23 December 2021 (2021-12-23), XP093011046, Retrieved from the Internet [retrieved on 20230102], DOI: 10.1101/2021.12.21.473680
KURBEGOVIC ALMIRA ET AL: "Novel Functional Complexity of Polycystin-1 by GPS Cleavage In Vivo : Role in Polycystic Kidney Disease", MOLECULAR AND CELLULAR BIOLOGY, vol. 34, no. 17, 1 September 2014 (2014-09-01), USA, pages 3341 - 3353, XP093117384, ISSN: 1098-5549, Retrieved from the Internet DOI: 10.1128/MCB.00687-14
XINLI SHAO: "A Minimal Ksp-Cadherin Promoter Linked to a Green Fluorescen... : Journal of the American Society of Nephrology", JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 1 July 2002 (2002-07-01), pages 1 - 19, XP93152041, Retrieved from the Internet DOI: 10.1097/01.ASN.0000016443.50138.CD
ONUCHIC LAURA ET AL: "The C-terminal tail of polycystin-1 suppresses cystic disease in a mitochondrial enzyme-dependent fashion", BIORXIV, 23 December 2021 (2021-12-23), XP093011046, Retrieved from the Internet
KURBEGOVIC ALMIRA ET AL: "Novel Functional Complexity of Polycystin-1 by GPS Cleavage In Vivo : Role in Polycystic Kidney Disease", MOLECULAR AND CELLULAR BIOLOGY, vol. 34, no. 17, 1 September 2014 (2014-09-01), USA, pages 3341 - 3353, XP093117384, ISSN: 1098-5549, Retrieved from the Internet
XINLI SHAO: "A Minimal Ksp-Cadherin Promoter Linked to a Green Fluorescen... : Journal of the American Society of Nephrology", JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 1 July 2002 (2002-07-01), pages 1 - 19, XP93152041, Retrieved from the Internet
Attorney, Agent or Firm:
MAIWALD GMBH (DE)
Download PDF: