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Title:
LONG-ACTING INSULIN ANALOGUE AND COMPLEX THEREOF
Document Type and Number:
WIPO Patent Application WO/2020/032422
Kind Code:
A1
Abstract:
The present invention relates to a long-acting insulin analogue having an increased half-life inside the body by having the 22nd amino acid of a B chain of natural insulin replaced and a portion of amino acids of an A chain or the B chain of the natural insulin additionally replaced, and to a long-acting insulin analogue complex having a further increased half life inside the body, as an albumin binding domain is additionally bound to the long-acting insulin analogue. The insulin analogue or the insulin analogue complex according to the present invention has a remarkably increased half-life inside the body and, thus, can provide convenience to diabetic patients who directly administer insulin as an injection.

Inventors:
AHN KYONG HOON (KR)
KWON OH-BYUNG (KR)
KIM SEUNG WOO (KR)
Application Number:
PCT/KR2019/008953
Publication Date:
February 13, 2020
Filing Date:
July 19, 2019
Export Citation:
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Assignee:
DAE WOONG PHARMA (KR)
International Classes:
C07K14/62; C12P21/00
Domestic Patent References:
WO2009115469A12009-09-24
WO2011161125A12011-12-29
WO2014048977A12014-04-03
Foreign References:
KR20150087130A2015-07-29
US20160289291A12016-10-06
KR20120135123A2012-12-12
CN101541830A2009-09-23
KR20150058454A2015-05-28
EP0368187A21990-05-16
US5750497A1998-05-12
US7615532B22009-11-10
US20110092419A12011-04-21
KR20150087130A2015-07-29
KR20150058454A2015-05-28
Other References:
BIOCHEM. J., vol. 312, 1995, pages 725 - 731
See also references of EP 3835314A4
Attorney, Agent or Firm:
LEE, Cheo Young et al. (KR)
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