Title:
MARKER FOR DIAGNOSING NON-ALCOHOLIC FATTY LIVER DISEASE
Document Type and Number:
WIPO Patent Application WO/2022/245066
Kind Code:
A1
Abstract:
The present invention relates to a marker for diagnosing non-alcoholic fatty liver disease and, more specifically, to: a composition and a kit which can diagnose non-alcoholic steatohepatitis (NASH) with high accuracy by comprising an agent for measuring the level of exosome-derived ApoA-1 (exosomal ApoA-1) protein; and a composition and a kit which can accurately predict prognosis after the administration of a therapeutic agent for non-alcoholic steatohepatitis. The composition and the kit of the present invention can be variously used for the diagnosis of non-alcoholic fatty liver disease, for the prognosis prediction of non-alcoholic fatty liver disease and as an agent for screening for therapeutic agents for non-alcoholic fatty liver disease.
Inventors:
KIM SUE (KR)
KIM JI MIN (KR)
KIM JI MIN (KR)
Application Number:
PCT/KR2022/006924
Publication Date:
November 24, 2022
Filing Date:
May 13, 2022
Export Citation:
Assignee:
BREXOGEN INC (KR)
International Classes:
G01N33/68
Domestic Patent References:
| WO2018037229A1 | 2018-03-01 |
Foreign References:
| US20060135420A1 | 2006-06-22 | |||
| US20080090223A1 | 2008-04-17 | |||
| US20200199575A1 | 2020-06-25 | |||
| KR20210024417A | 2021-03-05 |
Other References:
SUN, Y. ET AL.: "Lipid profile characterization and lipoprotein comparison of extracellular vesicles from human plasma and serum.", METABOLITES, vol. 9, no. 259, November 2019 (2019-11-01), pages 1 - 15, XP093008140
KARAVIA ELENI A, PAPACHRISTOU DIONYSIOS J, LIOPETA KASSIANI, TRIANTAPHYLLIDOU IRENE-EVA, DIMITRAKOPOULOS ODYSSEFS, KYPREOS KYRIAKO: "Apolipoprotein AI modulates processes associated with diet-induced nonalcoholic fatty liver disease in mice.", MOLECULAR MEDICINE, vol. 18, 2012, pages 901 - 912, XP093008145
KARAVIA ELENI A, PAPACHRISTOU DIONYSIOS J, LIOPETA KASSIANI, TRIANTAPHYLLIDOU IRENE-EVA, DIMITRAKOPOULOS ODYSSEFS, KYPREOS KYRIAKO: "Apolipoprotein AI modulates processes associated with diet-induced nonalcoholic fatty liver disease in mice.", MOLECULAR MEDICINE, vol. 18, 2012, pages 901 - 912, XP093008145
Attorney, Agent or Firm:
YOON, Dae Woong (KR)
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