Title:
PHARMACEUTICAL COMPOSITION FOR PREVENTION, ALLEVIATION OR TREATMENT OF MUSCULAR DYSTROPHY, CONTAINING RORα ACTIVATOR JC1-40
Document Type and Number:
WIPO Patent Application WO/2022/245067
Kind Code:
A1
Abstract:
The present invention relates to a pharmaceutical composition for the prevention, alleviation or treatment of muscular dystrophy, containing a RORα activator JC1-40. A composition according to the present invention increases mitochondrial membrane potential, increases the number of mitochondria, and increases the expression or activity of mitochondria-related genes or proteins to thus increase biosynthesis of mitochondria, and is thus expected to be effective in the prevention, alleviation and treatment of muscular dystrophy.
Inventors:
LEE MI-OCK (KR)
PARK HYEUNG-GEUN (KR)
KIM HYEON-JI (KR)
PARK HYEUNG-GEUN (KR)
KIM HYEON-JI (KR)
Application Number:
PCT/KR2022/006925
Publication Date:
November 24, 2022
Filing Date:
May 13, 2022
Export Citation:
Assignee:
SEOUL NAT UNIV R&DB FOUNDATION (KR)
International Classes:
A61P21/00; A61K31/17
Foreign References:
| US20180265462A1 | 2018-09-20 | |||
| KR20210005880A | 2021-01-15 |
Other References:
KIM HYEON-JI, HAN YONG-HYUN, NA HYELIN, KIM JU-YEON, KIM TAEWOOK, KIM HYE-JIN, SHIN CHANSEOK, LEE JUNG WEON, LEE MI-OCK: "Liver-specific deletion of RORα aggravates diet-induced nonalcoholic steatohepatitis by inducing mitochondrial dysfunction", SCIENTIFIC REPORTS, vol. 7, no. 16041, 1 December 2017 (2017-12-01), pages 1 - 11, XP093007559, DOI: 10.1038/s41598-017-16077-y
AZUMA KOTARO, IKEDA KAZUHIRO, INOUE SATOSHI: "Functional Mechanisms of Mitochondrial Respiratory Chain Supercomplex Assembly Factors and Their Involvement in Muscle Quality", INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 21, no. 3182, pages 1 - 17, XP093007574, DOI: 10.3390/ijms21093182
ANTON M. JETTEN, HONG SOON KANG, YUKIMASA TAKEDA: "Retinoic acid-related orphan receptors α and γ: key regulators of lipid/glucose metabolism, inflammation, and insulin sensitivity", FRONTIERS IN ENDOCRINOLOGY, vol. 4, pages 1 - 8, XP055159436, DOI: 10.3389/fendo.2013.00001
AZUMA KOTARO, IKEDA KAZUHIRO, INOUE SATOSHI: "Functional Mechanisms of Mitochondrial Respiratory Chain Supercomplex Assembly Factors and Their Involvement in Muscle Quality", INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 21, no. 3182, pages 1 - 17, XP093007574, DOI: 10.3390/ijms21093182
ANTON M. JETTEN, HONG SOON KANG, YUKIMASA TAKEDA: "Retinoic acid-related orphan receptors α and γ: key regulators of lipid/glucose metabolism, inflammation, and insulin sensitivity", FRONTIERS IN ENDOCRINOLOGY, vol. 4, pages 1 - 8, XP055159436, DOI: 10.3389/fendo.2013.00001
Attorney, Agent or Firm:
LEE, Myoung-Jin (KR)
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