Title:
MASS SPECTROSCOPE
Document Type and Number:
WIPO Patent Application WO/2010/001439
Kind Code:
A1
Abstract:
The MS analysis is performed for each of microscopic areas within a specified mass spectrometry range on a sample, and specified m/z or m/z range of distribution images are generated in accordance with the data derived from the MS analysis to be drawn on a display screen (S10 to S14). When an operator views such images to identify a substance of interest, and indicates the pertinent m/z (S15), microscopic areas the m/z intensity of which exceeds a threshold on the MS spectrum are extracted, and the MS/MS analysis is performed for the microscopic areas using m/z of the substance of interest as a precursor (S26, S27). An average MS/MS spectrum is calculated from the derived MS/MS spectrum data for each of the microscopic areas (S28), and the substance of interest is identified by the use of peak information appearing on the average MS/MS spectrum (S19).
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Inventors:
KAJIHARA SHIGEKI (JP)
Application Number:
PCT/JP2008/001760
Publication Date:
January 07, 2010
Filing Date:
July 03, 2008
Export Citation:
Assignee:
SHIMADZU CORP (JP)
KAJIHARA SHIGEKI (JP)
KAJIHARA SHIGEKI (JP)
International Classes:
G01N27/62
Domestic Patent References:
| WO2007020862A1 | 2007-02-22 |
Foreign References:
| JP2006337371A | 2006-12-14 |
Other References:
TAKAHIRO HARADA ET AL.: "Kenbi Shitsuryo Bunseki Sochi ni Yoru Seitai Soshiki Bunseki", SHIMADZU REVIEW, vol. 64, no. 3 TO 4, 24 April 2008 (2008-04-24), pages 139 - 146
SHUICHI SHIMADA ET AL.: "Mass Microscopy to Reveal Distinct Localization of Heme B (m/z 616) in Colon Cancer Liver Metastasis", JOURNAL OF THE MASS SPECTROMETRY SOCIETY OF JAPAN, vol. 55, no. 3, 2007, pages 145 - 148
KIYOSHI OGAWA ET AL.: "Kenbi Shitsuryo Bunseki Sochi no Kaihatsu", SHIMADZU REVIEW, vol. 62, no. 3 TO 4, 31 March 2006 (2006-03-31), pages 125 - 135
SHUICHI SHIMADA ET AL.: "Mass Microscopy to Reveal Distinct Localization of Heme B (m/z 616) in Colon Cancer Liver Metastasis", JOURNAL OF THE MASS SPECTROMETRY SOCIETY OF JAPAN, vol. 55, no. 3, 2007, pages 145 - 148
KIYOSHI OGAWA ET AL.: "Kenbi Shitsuryo Bunseki Sochi no Kaihatsu", SHIMADZU REVIEW, vol. 62, no. 3 TO 4, 31 March 2006 (2006-03-31), pages 125 - 135
Attorney, Agent or Firm:
KOBAYASI, Ryohei et al. (JP)
Ryohei Kobayashi (JP)
Ryohei Kobayashi (JP)
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