Title:
METHOD FOR ENHANCING ANTICANCER IMMUNOSTIMULATING CAPACITY OF DENDRITIC CELLS AND USE OF SAME
Document Type and Number:
WIPO Patent Application WO/2016/024628
Kind Code:
A1
Abstract:
Provided is a method with which it is possible to easily enhance the immunostimulating capacity of dendritic cells. A method for enhancing the anticancer immunostimulating capacity of dendritic cells, the method being characterized by including a treatment step for inhibiting the TGF-β of dendritic cells. This inhibition of TGF-β is, e.g., inhibition of the expression of Smad2 involved in the TGF-β signal.
Inventors:
MAMURA MIZUKO (JP)
YOON JEONG-HWAN (JP)
KURODA MASAHIKO (JP)
SUDO KATSUKO (JP)
YOON JEONG-HWAN (JP)
KURODA MASAHIKO (JP)
SUDO KATSUKO (JP)
Application Number:
PCT/JP2015/072929
Publication Date:
February 18, 2016
Filing Date:
August 13, 2015
Export Citation:
Assignee:
UNIV TOKYO MEDICAL (JP)
International Classes:
A61K45/00; A61K31/713; A61K48/00; A61P35/00; A61P37/04; A61P43/00; C12N5/10; C12N15/113
Domestic Patent References:
| WO2007088651A1 | 2007-08-09 |
Foreign References:
| JP2009512727A | 2009-03-26 | |||
| JP2014518064A | 2014-07-28 | |||
| JP2009521496A | 2009-06-04 |
Other References:
LIN CHEN-SI ET AL.: "IL -6 restores dendritic cell maturation inhibited by tumor-derived TGF- beta through interfering Smad 2/3 nuclear translocation", CYTOKINE, vol. 62, no. 3, 2013, pages 352 - 359, ISSN: 1043-4666
TERAMOTO K. ET AL.: "Improvement of the potency of the dendritic cell -based vaccine immunotherapy through local inhibition of TGF-beta in tumor-draining lymph nodes.", CANCER RESEARCH, vol. 73, no. 8, 15 April 2013 (2013-04-15)
TANAKA H. ET AL.: "Transforming growth factor signaling inhibitor, SB-431542, induces maturation of dendritic cells and enhances anti-tumor activity", ONCOLOGY REPORTS, vol. 24, no. 6, 2010, pages 1637 - 1643
WANG FU-LI ET AL.: "TGF-beta insensitive dendritic cells: an efficient vaccine for murine prostate cancer", CANCER IMMUNOLOGY IMMUNOTHERAPY, vol. 56, no. 11, 2007, pages 1785 - 1793, XP019539113, DOI: doi:10.1007/s00262-007-0322-3
CONROY H. ET AL.: "Gene silencing of TGF-beta1 enhances antitumor immunity induced with a dendritic cell vaccine by reducing tumor- associated regulatory T cells", CANCER IMMUNOLOGY IMMUNOTHERAPY, vol. 61, 2012, pages 425 - 431, XP035018865, DOI: doi:10.1007/s00262-011-1188-y
KASHIWAGI I. ET AL.: "Generatin of tolerogenic dendritic cells by Smad2-deficeincy", PROCEEDINGS OF THE JAPANESE SOCIETY FOR IMMUNOLOGY, vol. 141, 2012, pages 216
YOON JEONG-HWAN ET AL.: "Smad2 is the TGF-beta receptor-regulated Smad to suppress the immunogenicity of mouse and human dendritic cells", CANCER RESEARCH, vol. 73, 15 April 2013 (2013-04-15)
KOIDO, S. ET AL.: "Augmentation of antitumor immunity by fusions of ethanol-treated tumor cells and dendritic cells stimulated via dual TLRs through TGF-beta1 blockade and IL -12p70 production", PLOS ONE, vol. 8, no. 5, 2013, pages e63498, ISSN: 1932-6203
JOHNSEN S. A.: "Transcriptional regulation of Smad2 is required for enhancement of TGFbeta/Smad signaling by TGFbeta inducible early gene", JOURNAL OF CELLULAR BIOCHEMISTRY, vol. 87, 2002, pages 233 - 241
TERAMOTO K. ET AL.: "Improvement of the potency of the dendritic cell -based vaccine immunotherapy through local inhibition of TGF-beta in tumor-draining lymph nodes.", CANCER RESEARCH, vol. 73, no. 8, 15 April 2013 (2013-04-15)
TANAKA H. ET AL.: "Transforming growth factor signaling inhibitor, SB-431542, induces maturation of dendritic cells and enhances anti-tumor activity", ONCOLOGY REPORTS, vol. 24, no. 6, 2010, pages 1637 - 1643
WANG FU-LI ET AL.: "TGF-beta insensitive dendritic cells: an efficient vaccine for murine prostate cancer", CANCER IMMUNOLOGY IMMUNOTHERAPY, vol. 56, no. 11, 2007, pages 1785 - 1793, XP019539113, DOI: doi:10.1007/s00262-007-0322-3
CONROY H. ET AL.: "Gene silencing of TGF-beta1 enhances antitumor immunity induced with a dendritic cell vaccine by reducing tumor- associated regulatory T cells", CANCER IMMUNOLOGY IMMUNOTHERAPY, vol. 61, 2012, pages 425 - 431, XP035018865, DOI: doi:10.1007/s00262-011-1188-y
KASHIWAGI I. ET AL.: "Generatin of tolerogenic dendritic cells by Smad2-deficeincy", PROCEEDINGS OF THE JAPANESE SOCIETY FOR IMMUNOLOGY, vol. 141, 2012, pages 216
YOON JEONG-HWAN ET AL.: "Smad2 is the TGF-beta receptor-regulated Smad to suppress the immunogenicity of mouse and human dendritic cells", CANCER RESEARCH, vol. 73, 15 April 2013 (2013-04-15)
KOIDO, S. ET AL.: "Augmentation of antitumor immunity by fusions of ethanol-treated tumor cells and dendritic cells stimulated via dual TLRs through TGF-beta1 blockade and IL -12p70 production", PLOS ONE, vol. 8, no. 5, 2013, pages e63498, ISSN: 1932-6203
JOHNSEN S. A.: "Transcriptional regulation of Smad2 is required for enhancement of TGFbeta/Smad signaling by TGFbeta inducible early gene", JOURNAL OF CELLULAR BIOCHEMISTRY, vol. 87, 2002, pages 233 - 241
Attorney, Agent or Firm:
TSUJIMARU Koichiro et al. (JP)
Koichiro Tsujimaru (JP)
Koichiro Tsujimaru (JP)
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