Title:
METHOD FOR PREVENTING OR TREATING MTOR-ASSOCIATED DISEASES THROUGH REGULATION OF VEGFR-3 EXPRESSION
Document Type and Number:
WIPO Patent Application WO/2021/182900
Kind Code:
A3
Abstract:
The present invention relates to a composition for preventing or treating mammalian target of rapamycin (mTOR)-mediated diseases and deficient mTOR signaling-associated diseases. The present invention provides an efficient therapeutic target for various disease caused by hyperactivity or deficient activity of mTOR, on the basis of the novel discovery that the regulation of VEGFR-3 expression leads to the regulation of mTOR signaling pathway activity. The present invention, especially through VEGFR-3 activation, blocks hyperexcitable states of epilepsy and protects nerves, and thus can be effectively used as a fundamental therapeutic agent for status epilepticus, which is an incurable disease.
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Inventors:
KIM WON-JOO (KR)
JEONG KYOUNG HOON (KR)
JEONG KYOUNG HOON (KR)
Application Number:
PCT/KR2021/003051
Publication Date:
November 04, 2021
Filing Date:
March 11, 2021
Export Citation:
Assignee:
UNIV YONSEI IACF (KR)
International Classes:
A61K38/17; A61K31/4375; A61P19/00; A61P21/00; A61P25/00; A61P25/24; C12Q1/6886; G01N33/50; G01N33/68
Domestic Patent References:
| WO2014022879A1 | 2014-02-13 |
Foreign References:
| KR20030094395A | 2003-12-11 | |||
| KR20100135754A | 2010-12-27 |
Other References:
LUO YAN, LIU LEI, ROGERS DONNA, SU WEI, ODAKA YOSHINOBU, ZHOU HONGYU, CHEN WENXING, SHEN TAO, ALEXANDER J. STEVEN, HUANG SHILE: "Rapamycin Inhibits Lymphatic Endothelial Cell Tube Formation by Downregulating Vascular Endothelial Growth Factor Receptor 3 Protein Expression", NEOPLASIA, vol. 14, no. 3, 1 March 2012 (2012-03-01), pages 228 - 237, XP055862397, ISSN: 1476-5586, DOI: 10.1593/neo.111570
XINGMEI FENG,DAN HUANG,XIAOHUI LU,GUIJUAN FENG,JING XING,JUN LU,KE XU,WEIWEI XIA,YAN MENG,TAO TAO,LIREN LI,ZHIFENG GU: "Insulin-like growth factor 1 can promote proliferation and osteogenic differentiation of human dental pulp stem cells via mTOR pathway", DEVELOPMENT, GROWTH & DIFFERENTIATION, vol. 56, no. 9, 1 December 2014 (2014-12-01), US, pages 615 - 624, XP055862398, ISSN: 0012-1592, DOI: 10.1111/dgd.12179
KYOUNG HOON JEONG,KYUNG-OK CHO,MUN-YONG LEE,SEONG YUN KIM,WON-JOO KIM: "Vascular endothelial growth factor receptor-3 regulates astroglial glutamate transporter-1 expression via mTOR activation in reactive astrocytes following pilocarpine-induced status epilepticus", GLIA, vol. 69, no. 2, 1 February 2021 (2021-02-01), US, pages 296 - 309, XP055862401, ISSN: 0894-1491, DOI: 10.1002/glia.23897
XINGMEI FENG,DAN HUANG,XIAOHUI LU,GUIJUAN FENG,JING XING,JUN LU,KE XU,WEIWEI XIA,YAN MENG,TAO TAO,LIREN LI,ZHIFENG GU: "Insulin-like growth factor 1 can promote proliferation and osteogenic differentiation of human dental pulp stem cells via mTOR pathway", DEVELOPMENT, GROWTH & DIFFERENTIATION, vol. 56, no. 9, 1 December 2014 (2014-12-01), US, pages 615 - 624, XP055862398, ISSN: 0012-1592, DOI: 10.1111/dgd.12179
KYOUNG HOON JEONG,KYUNG-OK CHO,MUN-YONG LEE,SEONG YUN KIM,WON-JOO KIM: "Vascular endothelial growth factor receptor-3 regulates astroglial glutamate transporter-1 expression via mTOR activation in reactive astrocytes following pilocarpine-induced status epilepticus", GLIA, vol. 69, no. 2, 1 February 2021 (2021-02-01), US, pages 296 - 309, XP055862401, ISSN: 0894-1491, DOI: 10.1002/glia.23897
Attorney, Agent or Firm:
PADO IP LAW PLLC (KR)
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