Title:
METHOD FOR SCREENING DRUG CANDIDATES BY USING DOMAIN PROTEIN
Document Type and Number:
WIPO Patent Application WO2007136146
Kind Code:
A9
Abstract:
The present invention relates to a method for screening and discovering bioactive materials using specifically selected protein domains interacting with specific intracellular proteins, and more particularly, to (1) a screening method including confirmation of changes in biological activities by introducing a specific protein domain into microorganisms or animal and plant cells and (2) a screening method including confirmation of changes in biological activities after introducing the specific protein domains into a number of microorganisms or animal and plant cells. Via this method, according to the present invention, it is possible that the selected protein domains can be used to develop novel antibiotic agents with antimicrobial activity effective on bacteria resistant to conventional antibiotics while requiring less genetic information compared with a conventional drug which targets specific genes.
Inventors:
KIM HYONG-HA (KR)
SUH JUNG-KEUN (KR)
SUH JUNG-KEUN (KR)
Application Number:
PCT/KR2006/001928
Publication Date:
December 24, 2008
Filing Date:
May 23, 2006
Export Citation:
Assignee:
KOREA RES INST OF STANDARDS (KR)
KIM HYONG-HA (KR)
SUH JUNG-KEUN (KR)
KIM HYONG-HA (KR)
SUH JUNG-KEUN (KR)
International Classes:
C12Q1/68
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