A METHOD FOR THE SEPARATION ANTI-AMYLOID BETA ANTIBODY WITH AMYLOID BETA PEPTIDE

WIPO Patent Application WO2005037209

A3

The present invention is a method of effectively dissociating an antibody and antigen from the complex they form. The method enables researchers to accurately identify anti-amyloid beta peptide and its antibody from sera samples. It can also be used for the evaluation of the outcome of Alzheimer's patient treatment based on the amyloid peptide load and antibody level in the sera.

WO/1993/003175	METHOD AND DEVICE FOR DETECTING THE PRESENCE OF ANALYTE IN A SAMPLE
WO/1999/021575	CHEMOKINE ALPHA-6

CAO CHUANHAI (US)
LI QINGYOU (US)
MORGAN DAVID G (US)
UGEN KENNETH E (US)

PCT/US2004/033748

March 23, 2006

October 14, 2004

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UNIV SOUTH FLORIDA (US)
CAO CHUANHAI (US)
LI QINGYOU (US)
MORGAN DAVID G (US)
UGEN KENNETH E (US)

G01N33/537; C07K16/06; C07K16/18; G01N33/536; G01N33/564; A61K

RAAM ET AL: "Freezing and thawing as a means of dissociating antigen bound to immobilized antibody", IMMUNOCHEMISTRY, vol. 12, no. 9, 1975, pages 723 - 726, XP002994874
BLANCHARD ET AL: "Regeneration of immunosorbent surfaces used in clinical, industrial and environmental biosensors", J. IMMUNOL. METHODS, vol. 130, no. 2, 1990, pages 263 - 275, XP002994875
KUMAGAI ET AL: "Studies of surface immunoglobulins on human B lymphocytes", J. IMMUNOLOGY, vol. 115, October 1975 (1975-10-01), pages 982 - 987, XP002508156

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