Title:
METHODS AND COMPOSITIONS FOR IDENTIFYING THERAPEUTIC COMPOUNDS
Document Type and Number:
WIPO Patent Application WO2005047898
Kind Code:
A3
Abstract:
By the present invention, enzymes responsible for prodrug activation are identified and utilized for the identification of candidate compounds as prodrugs. The present invention includes methods for identifying a candidate compound as a suitable prodrug as well as methods of screening candidate compounds for suitability as therapeutic agents.
Inventors:
MCDERMOTT MARTIN (US)
Application Number:
PCT/US2004/035083
Publication Date:
September 15, 2005
Filing Date:
October 22, 2004
Export Citation:
Assignee:
GILEAD SCIENCES INC (US)
MCDERMOTT MARTIN (US)
MCDERMOTT MARTIN (US)
International Classes:
A61K31/7072; A61K31/7076; C12Q1/34; C12Q1/42; C12Q1/44; C12Q1/70; G01N33/53; (IPC1-7): C12Q1/44
Domestic Patent References:
| WO1997015588A1 | 1997-05-01 |
Foreign References:
| US20020119443A1 | 2002-08-29 |
Other References:
VALETTE G ET AL: "DECOMPOSITION PATHWAYS AND IN VITRO HIV INHIBITORY EFFECTS OF ISODDA PRONUCLEOTIDES: TOWARD A RATIONAL APPROACH FOR INTRACELLULARDELIVERY OF NUCLEOSIDE 5'-MONOPHOSPHATES", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY. WASHINGTON, US, vol. 39, no. 10, 1996, pages 1981 - 1990, XP000578129, ISSN: 0022-2623
BALLATORE C ET AL: "SYNTHESIS AND EVALUATION OF NOVEL AMIDATE PRODRUGS OF PMEA AND PMPA", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, OXFORD, GB, vol. 11, 2001, pages 1053 - 1056, XP001180825, ISSN: 0960-894X
BALLATORE C ET AL: "SYNTHESIS AND EVALUATION OF NOVEL AMIDATE PRODRUGS OF PMEA AND PMPA", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, OXFORD, GB, vol. 11, 2001, pages 1053 - 1056, XP001180825, ISSN: 0960-894X
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