METHOD OF DIAGNOSING ALZHEIMER’S DISEASE

Title:

METHOD OF DIAGNOSING ALZHEIMER’S DISEASE

Document Type and Number:

WIPO Patent Application WO/2005/047897

Kind Code:

A1

Abstract:

A method of diagnosing isolated Alzheimer’s disease through detection of any increase of β-secretase activity. There is provided a method of diagnosing Alzheimer’s disease, comprising detecting or measuring any secretory sialic acid transferase broken by β-secretase contained in a sample from human.

Inventors:

KITAZUME SHINOBU (JP)
TACHIDA YURIKO (JP)
OKA RITSUKO (JP)
HASHIMOTO YASUHIRO (JP)
SAIDOH TAKAOMI (JP)

Application Number:

PCT/JP2004/017218

Publication Date:

May 26, 2005

Filing Date:

November 12, 2004

Export Citation:

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Assignee:

RIKEN (JP)
KITAZUME SHINOBU (JP)
TACHIDA YURIKO (JP)
OKA RITSUKO (JP)
HASHIMOTO YASUHIRO (JP)
SAIDOH TAKAOMI (JP)

International Classes:

C07K16/40; C12Q1/37; G01N33/50; G01N33/573; G01N33/68; (IPC1-7): G01N33/50; C12Q1/37; G01N33/573

Domestic Patent References:

WO2002094985A2	2002-11-28
WO2002058323A2	2002-07-25

Foreign References:

JPH11507538A

1999-07-06

Other References:

KITAZUME, S. ET AL.: "Alzheimer's beta-secretase, beta-site amyloidprecursor protein-cleaving enzyme, is responsible for cleavage secretion of a Golgi-residentsialyltransferase", PNAS, vol. 98, no. 24, November 2001 (2001-11-01), pages 13554 - 13559, XP002224671
KITAZUME, S. ET AL.: "Characterization of alpha2, 6-sialyltransferase cleavage by Alzheimer's beta-secreatase (BACE1)", JBC, vol. 275, no. 17, April 2003 (2003-04-01), pages 14865 - 14871, XP002983655

Attorney, Agent or Firm:

SIKS & CO. (Kyobashi-Nisshoku Bldg. 8-, Kyobashi 1-chome Chuo-ku Saitama 31, JP)

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