Title:
METHODS FOR MODULATING A POPULATION OF MYELOID-DERIVED SUPPRESSOR CELLS AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO/2009/097394
Kind Code:
A3
Abstract:
The invention provides for methods of modulating a population of myeloid-derived suppressor cells (MDSCs) in a subject, for treating an autoimmune disease, and also treating cancer in a subject in need thereof. The methods comprise administering to the subject a therapeutically effective amount of an agent that modulates the Tim-3 pathway. The Tim-3 pathway can be activated by a Tim-3 ligand, galectin-9, whereby MDSCs are expanded, or inhibited by an antibody to Tim-3, wherein the expansion of MDSCs is inhibited.
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Inventors:
KUCHROO VIJAY (US)
ANDERSON ANA (US)
DARDALHON VALERIE (US)
ANDERSON ANA (US)
DARDALHON VALERIE (US)
Application Number:
PCT/US2009/032372
Publication Date:
December 23, 2010
Filing Date:
January 29, 2009
Export Citation:
Assignee:
BRIGHAM & WOMENS HOSPITAL (US)
KUCHROO VIJAY (US)
ANDERSON ANA (US)
DARDALHON VALERIE (US)
KUCHROO VIJAY (US)
ANDERSON ANA (US)
DARDALHON VALERIE (US)
International Classes:
A61P31/04; A61K38/17; A61P31/10; A61P31/12; A61P33/00; A61P35/00; A61P37/04; A61P37/06; C07K16/28
Domestic Patent References:
| WO2003063792A2 | 2003-08-07 | |||
| WO1999010490A1 | 1999-03-04 |
Foreign References:
| US20050276756A1 | 2005-12-15 | |||
| US20050191721A1 | 2005-09-01 | |||
| EP1736541A1 | 2006-12-27 | |||
| EP1586325A1 | 2005-10-19 |
Other References:
ANDERSON D E: "TIM-3 as a therapeutic target in human inflammatory diseases", EXPERT OPINION ON THERAPEUTIC TARGETS,, vol. 11, no. 8, 1 August 2007 (2007-08-01), pages 1005 - 1009, XP009101647, ISSN: 1744-7631
WANG ET AL: "The Tim-3 ligand galectin-9 negatively regulates CD8<+> alloreactive T cell and prolongs survival of skin graft", CELLULAR IMMUNOLOGY, ACADEMIC PRESS, SAN DIEGO, CA, US, vol. 250, no. 1-2, 2007, pages 68 - 74, XP022559224, ISSN: 0008-8749
SEKI MASAKO ET AL: "Beneficial effect of galectin 9 on rheumatoid arthritis by induction of apoptosis of synovial fibroblasts", ARTHRITIS & RHEUMATISM, JOHN WILEY & SONS, INC, US LNKD- DOI:10.1002/ART.23076, vol. 56, no. 12, 1 December 2007 (2007-12-01), pages 3968 - 3976, XP009140525, ISSN: 0004-3591, [retrieved on 20071129]
DATABASE WPI Week 200636, Derwent World Patents Index; AN 2006-347101, XP002607190
DATABASE WPI Week 200756, Derwent World Patents Index; AN 2007-576972, XP002607241
DATABASE WPI Week 200770, Derwent World Patents Index; AN 2007-744729, XP002607242
DARDALHON V ET AL: "OR.26. Tim-3:Galectin-9 Pathway Expands Myeloid Suppressor Cells", CLINICAL IMMUNOLOGY, ACADEMIC PRESS, US LNKD- DOI:10.1016/J.CLIM.2008.03.031, vol. 127, 1 January 2008 (2008-01-01), pages S12, XP022615826, ISSN: 1521-6616, [retrieved on 20080101]
WANG ET AL: "The Tim-3 ligand galectin-9 negatively regulates CD8<+> alloreactive T cell and prolongs survival of skin graft", CELLULAR IMMUNOLOGY, ACADEMIC PRESS, SAN DIEGO, CA, US, vol. 250, no. 1-2, 2007, pages 68 - 74, XP022559224, ISSN: 0008-8749
SEKI MASAKO ET AL: "Beneficial effect of galectin 9 on rheumatoid arthritis by induction of apoptosis of synovial fibroblasts", ARTHRITIS & RHEUMATISM, JOHN WILEY & SONS, INC, US LNKD- DOI:10.1002/ART.23076, vol. 56, no. 12, 1 December 2007 (2007-12-01), pages 3968 - 3976, XP009140525, ISSN: 0004-3591, [retrieved on 20071129]
DATABASE WPI Week 200636, Derwent World Patents Index; AN 2006-347101, XP002607190
DATABASE WPI Week 200756, Derwent World Patents Index; AN 2007-576972, XP002607241
DATABASE WPI Week 200770, Derwent World Patents Index; AN 2007-744729, XP002607242
DARDALHON V ET AL: "OR.26. Tim-3:Galectin-9 Pathway Expands Myeloid Suppressor Cells", CLINICAL IMMUNOLOGY, ACADEMIC PRESS, US LNKD- DOI:10.1016/J.CLIM.2008.03.031, vol. 127, 1 January 2008 (2008-01-01), pages S12, XP022615826, ISSN: 1521-6616, [retrieved on 20080101]
Attorney, Agent or Firm:
RESNICK, David et al. (100 Summer StreetBoston, Massachusetts, US)
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